Table 2.
No. of studies | OR (95% CI) | P | I2 | ph | Model | Publication bias | ||
---|---|---|---|---|---|---|---|---|
|
||||||||
Egger | Begg | |||||||
-308G>A | ||||||||
Dominant model (GG+GA vs. AA) | 14 | 0.53 (0.35-0.81) | 0.004 | 26.2% | 0.17 | Fix | 0.83 | 0.66 |
Recessive model (GG vs. GA+AA) | 17 | 0.83 (0.62-1.10) | 0.19 | 65.4% | <0.001 | Random | 0.90 | 0.82 |
Homozygote model (GG vs. AA) | 14 | 0.51 (0.33-0.78) | 0.002 | 35.6% | 0.09 | Fix | 0.84 | 0.83 |
Additive model (G vs. A) | 17 | 0.81 (0.63-1.04) | 0.11 | 68.0% | <0.001 | Random | 0.43 | 0.77 |
-863C>A | ||||||||
Dominant model (CC+CA vs. AA) | 4 | 0.78 (0.25-2.47) | 0.67 | 72.8% | 0.01 | Random | 0.03 | 0.73 |
Recessive model (CC vs. CA+AA) | 4 | 1.01 (0.83-1.22) | 0.96 | 0 | 0.72 | Fix | 0.06 | 0.31 |
Homozygote model (CC vs. AA) | 4 | 0.80 (0.25-2.53) | 0.70 | 71.7% | 0.01 | Random | 0.10 | 0.73 |
Additive model (C vs. A) | 4 | 1.08 (0.80-1.47) | 0.61 | 61.0% | 0.05 | Random | 0.88 | 0.73 |
-857C>T | ||||||||
Dominant model (CC+CT vs. TT) | 5 | 2.10 (0.77-5.75) | 0.15 | 54.0% | 0.07 | Random | 0.42 | 0.81 |
Recessive model (CC vs. CT+TT) | 5 | 0.84 (0.45-1.57) | 0.59 | 85.0% | <0.001 | Random | 0.24 | 0.46 |
Homozygote model (CC vs. TT) | 5 | 2.11 (0.72-6.12) | 0.17 | 58.6% | 0.047 | Random | 0.61 | 1.00 |
Homozygote model (C vs. T) | 5 | 0.92 (0.55-1.53) | 0.73 | 84.5% | <0.001 | Random | 0.13 | 0.46 |
-238G>A | ||||||||
Dominant model (GG+GA vs. AA) | 4 | 0.33 (0.18-0.57) | <0.001 | 19.9% | 0.29 | Fix | 0.33 | 0.09 |
Recessive model (GG vs. GA+AA) | 8 | 0.62 (0.30-1.30) | 0.21 | 85.4% | <0.001 | Random | 0.59 | 0.71 |
Homozygote model (GG vs. AA) | 4 | 0.34 (0.06-2.12) | 0.25 | 56.1% | 0.078 | Random | 0.17 | 0.31 |
Additive model (G vs. A) | 8 | 0.67 (0.35-1.26) | 0.21 | 85.4% | <0.001 | Random | 0.32 | 0.39 |
Note. OR: Odds ratio; CI: Confidence interval; ph: P value of heterogeneity.