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Trial profile. Flow-mediated dilation (FMD) of the radial artery was assessed before 15 min of arm ischemia reperfusion (IR) and at 15 min of reperfusion (A~F). Remote ischemic preconditioning (RIPC) was applied immediately (B, D) and 24 h (C, F) before IR. The COX-2 inhibitor celecoxib (200 mg orally twice daily) was administered for 5 days (D~F).
