Table 2.

Univariate and multivariate analyses for overall survival by Cox regression model

Parameters	Univariate analysis			Multivariate analysis
	HR	95% CI	P	HR	95% CI	P
Age	1.014	0.281-1.635	0.810
Gender	1.473	0.544-2.162	0.502
LN metastasis	2.823	1.393-5.709	0.026	3.027	1.721-7.039	0.034
Distant metastasis	3.562	1.830-7.814	0.009	3.653	2.350-8.931	0.013
Surgery margins	1.215	0.687-1.891	0.628
TNM stage	4.067	2.535-9.952	0.005	4.815	2.960-12.851	0.002
Grade	2.058	0.975-3.857	0.054
Family history	1.793	0.611-2.925	0.124
Tissue miR-345	3.398	1.763-7.260	0.011	3.921	2.285-10.540	0.008