Table 1.
Main characteristics of studies selected in the meta-analysis
| ID | First author | Year | Genotyping method | Country | Ethnicity | SNP | ||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| rs6983267 | rs10505477 | rs7014346 | rs7837328 | rs16892766 | ||||||
|
| ||||||||||
| Case/Cont | Case/Cont | Case/Cont | Case/Cont | Case/Cont | ||||||
| 1 | Gruber | 2007 | GeneChip | Northern Israel | Asian | -- | 1861/1937 | -- | -- | -- |
| 2 | Poynter | 2007 | PCR | Europe | Caucasian | 1339/2191 | 1341/2193 | -- | -- | -- |
| 3 | Tomlinson | 2007 | Illumina | United Kingdom | Caucasian | 7954/6202 | -- | -- | -- | -- |
| 4 | Zanke | 2007 | TaqMan | Newfoundland, Canada | Caucasian | -- | 445/366 | -- | -- | -- |
| 5 | Zanke | 2007 | TaqMan | America | Caucasian | -- | 1859/1882 | -- | -- | -- |
| 6 | Zanke | 2007 | TaqMan | Scotland | Caucasian | -- | 2809/2912 | -- | -- | -- |
| 7 | Zanke | 2007 | TaqMan | France | Caucasian | -- | 1415/1656 | -- | -- | -- |
| 8 | Zanke | 2007 | TaqMan | Europe | Caucasian | -- | 761/749 | -- | -- | -- |
| 9 | Li | 2008 | TaqMan | America | Caucasian | 527/679 | -- | -- | -- | -- |
| 10 | Pittman | 2008 | PCR | United Kingdom | Caucasian | 3583/2579 | -- | -- | -- | -- |
| 11 | Schafmayer | 2008 | SNPlex | German | Caucasian | 2712/2713 | 2713/2718 | 2713/2718 | -- | -- |
| 12 | Tenesa | 2008 | Illumina | Scotland | Caucasian | -- | -- | 2986/3059 | -- | -- |
| 13 | Tenesa | 2008 | Illumina | Japan | Caucasian | -- | -- | 4395/3179 | -- | -- |
| 14 | Tenesa | 2008 | Illumina | Canada | Caucasian | -- | -- | 1175/1183 | -- | -- |
| 15 | Tenesa | 2008 | Illumina | England | Caucasian | -- | -- | 2233/2248 | -- | -- |
| 16 | Tenesa | 2008 | Illumina | Spain | Caucasian | -- | -- | 349/292 | -- | -- |
| 17 | Tenesa | 2008 | Illumina | Germany | Caucasian | -- | -- | 3455/3563 | -- | -- |
| 18 | Tenesa | 2008 | Illumina | Scotland | Caucasian | -- | -- | 826/892 | -- | -- |
| 19 | Tenesa | 2008 | Illumina | Israel | Caucasian | -- | -- | 1517/1466 | -- | -- |
| 20 | Tomlinson | 2008 | Illumina | United Kingdom | Caucasian | -- | -- | -- | -- | 18831/18540 |
| 21 | Tuupanen | 2008 | PCR | Finland | Caucasian | 996/1012 | -- | -- | -- | -- |
| 22 | Wokołorczyk | 2008 | RFLP-PCR | Poland | Caucasian | 779/1910 | -- | -- | -- | -- |
| 23 | Curtin | 2009 | SNPlex | United Kingdom | Caucasian | 1069/1040 | 1071/1040 | -- | -- | -- |
| 24 | Kupfer | 2009 | Sequenom MassARRAY | America (European) | Caucasian | 288/202 | -- | -- | -- | -- |
| 25 | Matsuo | 2009 | TaqMan | Japan | Asian | 476/961 | -- | -- | -- | -- |
| 26 | Middeldorp | 2009 | PCR | Dutch | Caucasian | 995/1340 | -- | -- | -- | -- |
| 27 | Cui | 2010 | Illumina | Japan | Asian | 6161/4494 | -- | -- | 6163/4494 | -- |
| 28 | Ghazi | 2010 | TaqMan | Sweden | Caucasian | 511/1017 | -- | -- | -- | -- |
| 29 | Holst | 2010 | TaqMan | Sweden | Caucasian | 1737/1738 | -- | -- | -- | 1755/1691 |
| 30 | Hutter | 2010 | TaqMan | Iran | Asian | 1962/2418 | 2089/2443 | -- | -- | -- |
| 31 | Kupfer | 2010 | Sequenom MassARRAY | America (European) | Caucasian | 399/367 | -- | 399/367 | 399/367 | 399/367 |
| 32 | Kupfer | 2010 | Sequenom MassARRAY | America (African) | African | 795/985 | -- | 795/985 | 795/985 | 795/985 |
| 33 | Xiong | 2010 | RFLP-PCR | China | Asian | 2124/2124 | -- | -- | -- | -- |
| 34 | He | 2011 | TaqMan | America (European) | Caucasian | 1171/1543 | -- | -- | -- | 1171/1543 |
| 35 | He | 2011 | TaqMan | America (African) | African | 382/510 | -- | -- | -- | 382/510 |
| 36 | He | 2011 | TaqMan | America (Native Hawaiians) | Caucasian | 323/472 | -- | -- | -- | 323/472 |
| 37 | He | 2011 | TaqMan | America (Japanese) | Asian | 1042/1426 | -- | -- | -- | 1042/1426 |
| 38 | He | 2011 | TaqMan | America (Latino) | Caucasian | 393/524 | -- | -- | -- | 393/524 |
| 39 | Ho | 2011 | Sequenom MassARRAY | China | Asian | 716/714 | -- | 716/714 | -- | -- |
| 40 | Li | 2011 | TaqMan | China | Asian | 430/786 | -- | -- | -- | -- |
| 41 | Lubbe | 2011 | PCR | United Kingdom | Caucasian | 8878/6051 | -- | -- | -- | -- |
| 42 | Daraei | 2012 | PCR–RFLP | Iran | Asian | 110/120 | -- | -- | -- | -- |
| 43 | Peters | 2012 | Illumina | -- | Caucasian | 4166/4990 | -- | -- | -- | 7686/8977 |
| 44 | Thean | 2012 | Affymetrix GeneChip | Singapore | Asian | 1000/1000 | -- | -- | -- | 991/993 |
| 45 | Hong | 2013 | TaqMan | Korea | Asian | 198/328 | -- | -- | -- | -- |
| 46 | Nan | 2013 | TaqMan | America | Caucasian | 807/1623 | -- | -- | -- | -- |
| 47 | Wang | 2013 | Illumina | America (African) | African | 1894/4703 | 1894/4703 | 1894/4703 | 1894/4703 | |
| 48 | Yang | 2014 | TaqMan | America | Caucasian | 90/132 | -- | -- | 90/132 | -- |
| 49 | Yang | 2014 | Sequenom MassARRAY | Taiwan | Asian | 705/1802 | 705/1802 | 705/1802 | -- | -- |