Table 1.
Pharmacokinetic parameters of bupropion and omeprazole in control-group and Radix sophorae flavescentis-group rats (mean ± SD, n=10)
| Parameters | AUC(0-t) | AUC(0-∞) | t1/2 | CL | V | Cmax | |
|---|---|---|---|---|---|---|---|
|
| |||||||
| ng/mL*h | ng/mL*h | h | L/h/kg | L/kg | ng/mL | ||
| Bupropion | Control | 255.7±297.7 | 284.7±333.7 | 2.5±0.5 | 88.6±65.7 | 337.0±326.7 | 131.4±146.2 |
| Radix sophorae flavescentis | 151.1±133.9 | 156.8±135.9 | 1.6±0.7* | 93.2±44.2 | 225.5±154.5 | 62.1±59.1 | |
| Omeprazole | Control | 58.8±13.6 | 62.9±16.4 | 0.8±0.7 | 169.0±46.6 | 182.6±114.9 | 63.0±22.2 |
| Radix sophorae flavescentis | 144.5±59.4** | 147.4±61.5** | 0.6±0.1 | 86.5±59.9* | 77.9±61.3 | 213.4±84.8** | |
Compared Radix sophorae flavescentis group with the control group;
*
P<0.05;
**
P<0.01.