Table 2.
Pharmacokinetic parameters of and phenacetin and tolbutamide in control-group and Radix sophorae flavescentis -group rats (Mean ± SD, n=10)
| Parameters | AUC(0-t) | AUC(0-∞) | t1/2 | CL | V | Cmax | |
|---|---|---|---|---|---|---|---|
|
| |||||||
| ng/mL*h | ng/mL*h | h | L/h/kg | L/kg | ng/mL | ||
| Phenacetin | Control | 376.3±130.5 | 380.1±127.1 | 1.4±0.9 | 28.9±9.6 | 66.4±57.5 | 546.5±109.0 |
| Radix sophorae flavescentis | 1849.5±1129.7* | 1851.1±1129.6* | 0.7±0.3 | 7.5±4.4** | 7.2±5.8* | 1530.9±658.8* | |
| Tolbutamide | Control | 52607.0±13518.7 | 193505.7±148512.1 | 65.6±50.2 | 0.008±0.008 | 0.535±0.260 | 1893.6±560.8 |
| Radix sophorae flavescentis | 56765.5±21022.1 | 57620.5±21275.2* | 5.7±1.7* | 0.020±0.007* | 0.157±0.059** | 5336.6±2942.6** | |
Compared Radix sophorae flavescentis group with the control group;
*
P<0.05;
**
P<0.01.