Table 3.
Pharmacokinetic parameters of midazolam and metroprolol in control-group and Radix sophorae flavescentis-group rats (Mean ± SD, n=10)
| Parameters | AUC(0-t) | AUC(0-∞) | t1/2 | CL | V | Cmax | |
|---|---|---|---|---|---|---|---|
|
| |||||||
| ng/mL*h | ng/mL*h | h | L/h/kg | L/kg | ng/mL | ||
| Midazolam | Control | 342.1±154.4 | 375.1±173.4 | 1.1±0.2 | 37.7±32.1 | 53.3±36.8 | 214.9±89.3 |
| Radix sophorae flavescentis | 300.9±78.1 | 332.1±89.2 | 1.1±0.3 | 31.9±8.7 | 51.0±21.9 | 180.6±59.6 | |
| Metroprolol | Control | 1139.5±249.1 | 1241.6±293.0 | 1.6±0.2 | 8.4±1.9 | 19.2±4.4 | 606.0±149.2 |
| Radix sophorae flavescentis | 538.2±234.0** | 551.6±226.8** | 0.8±0.2** | 22.9±15.0* | 31.6±30.9 | 304.2±133.2** | |
Compared Radix sophorae flavescentis group with the control group;
*
P<0.05;
**
P<0.01.