Table 2.
Meta-analysis of the association of TGF-β1 polymorphisms with the risk of DM
| Genetic variant | DM | Studies | Q test | Model selected | OR (95% CI) | P-value |
|---|---|---|---|---|---|---|
|
|
||||||
| p-value | ||||||
| TGF-β1 codon 10 | ||||||
| C vs T | T1DM | 3 | 0.066 | Random | 0.901 (0.698-1.162) | 0.421 |
| T2DM | 3 | 0.033 | Random | 1.304 (0.858-1.984) | 0.214 | |
| CC vs (CT+TT) | T1DM | 3 | 0.137 | Fixed | 0.738 (0.478-1.140) | 0.171 |
| T2DM | 3 | 0.406 | Fixed | 1.397 (1.041-1.874) | 0.026 | |
| TT vs (CT+CC) | T1DM | 3 | 0.022 | Random | 1.043 (0.663-1.640) | 0.856 |
| T2DM | 3 | 0.095 | Fixed | 0.826 (0.528-1.292) | 0.402 | |
| Sensitivity analysis | ||||||
| C vs T | T1DM | 2 | 0.021 | Random | 0.875 (0.531-1.441) | 0.601 |
| CC vs (CT+TT) | T1DM | 2 | 0.107 | Fixed | 0.862 (0.415-1.791) | 0.690 |
| TT vs (CT+CC) | T1DM | 2 | 0.024 | Random | 1.202 (0.601-2.402) | 0.603 |
| TGF-β1 codon 25 | ||||||
| G vs C | T1DM | 2 | 0.767 | Fixed | 1.019 (0.866-1.199) | 0.820 |
| T2DM | 2 | 0.790 | Fixed | 1.010 (0.789-1.292) | 0.939 | |
| GG vs (GC+CC) | T1DM | 2 | 0.674 | Fixed | 1.044 (0.825-1.320) | 0.721 |
| T2DM | 2 | 0.876 | Fixed | 0.949 (0.664-1.356) | 0.774 | |
| CC vs (GC+GG) | T1DM | 2 | 0.738 | Fixed | 1.802 (0.282-11.520) | 0.534 |
| T2DM | 2 | 0.085 | Fixed | 0.532 (0.020-14.194) | 0.706 | |
| Sensitivity analysis | ||||||
| G vs C | T2DM | 1 | - | Fixed | 0.955 (0.593-1.539) | 0.851 |
| GG vs (GC+CC) | T2DM | 1 | - | Fixed | 0.905 (0.454-1.805) | 0.778 |
| CC vs (GC+GG) | T2DM | 1 | - | Fixed | 3.646 (0.144-92.551) | 0.433 |
OR: odds ratio, CI = confidence interval.