Table 2.
Significant volume differences in the group by gender interaction:
(BD males ↓/HV males ↑/BD females ↑/HV females ↓).
| Structure | Peak voxel MNI coordinates (x, y, z) | Z-score | Cluster extent | P-value FWE corrected | Extends into |
|---|---|---|---|---|---|
| R fusiform gyrus | (34, 2, − 36) | 5.09 | 10,999 | 0.000 | Ventral striatum L amygdala R temporal inferior L fusiform L & R hippocampus R parahippocampal |
| R supplementary motor area | (2, 6, 70) | 4.66 | 1101 | 0.000 | R frontal SUPERIOR |
| L temporal middle lobe | (− 54, − 18, − 20) | 5.95 | 3380 | 0.000 | L temporal inferior R fusiform |
| R frontal inferior operculum | (60, 24, 27) | 4.69 | 698 | 0.002 | L postcentral |
| L frontal inferior operculum | (− 62,14,16) | 4.98 | 570 | 0.005 | L frontal inferior triangularis |
| R postcentral gyrus | (24, − 39, 45) | 5.49 | 2032 | 0.000 | L precuneus |
| L precuneus | (− 16, − 51, 51) | 5.06 | 1041 | 0.000 | L precuneus R SMA R paracentral lobule |
| R Medial Superior Frontal Cortex | (8, 33, 64) | 4.60 | 436 | 0.011 | |
| L Caudate | (− 10, 24, 4) | 4.37 | 535 | 0.006 | L putamen |
MNI: Montreal Neurological Institute, L: left, R: right. Results reported in the following tables using cluster extent thresholds were generated from statistical parametric maps at a threshold of P < 0.0001 whole brain uncorrected. Anatomical localizations were performed using the Automatic Anatomical Labeling (AAL) atlas (see Methods for more details).