. Author manuscript; available in PMC: 2017 Jan 26.

Published in final edited form as: J Am Coll Cardiol. 2016 Jan 26;67(3):239–247. doi: 10.1016/j.jacc.2015.10.080

Table 3a. Association between HbA1c values and incidence of ischemic stroke.

	HbA1c < 7.0%	HbA1c 7.0-8.9%	HbA1c ≥ 9.0%
Baseline HbA1c Values

Ischemic stroke events	58	50	29

Person-years (py)	2198.6	1754.2	1009.8

Rate	2.6/100py	2.9/100py	2.9/100py

Hazard Ratio (unadjusted)	Reference	1.09 (0.75-1.60)	1.10 (0.70-1.72)

Hazard Ratio (adjusted^*)	Reference	1.03 (0.69-1.54)	1.05 (0.66-1.66)

Time-Varying HbA1c Values
Ischemic stroke events	42	46	16
Person-years (py)	1690.8	1545.3	581.9
Rate	2.5/100 py	3.0/100 py	2.7/100 py
Hazard Ratio (unadjusted)	Reference	1.22 (0.80-1.87)	1.11 (0.63-1.98)
Hazard Ratio (adjusted^*)	Reference	1.21 (0.77-1.91)	1.04 (0.57-1.92)

Adjusted for age, gender, race, education, income, congestive heart failure, hypertension, prior ischemic stroke, coronary artery disease, peripheral arterial disease, proteinuria, significant kidney dysfunction, insulin use, and diabetes duration

Py = person-years