Table 3. Net Reclassification Improvement: Risk Markers Added to cPCE.

	cPCE Alone
cPCE + Marker	<7.5%	≥7.5 %	Row Total	NRI (95% CI)
cPCE + CAC
Event (n = 320)
<7.5%	107	19	126 (39.4)	0.178 (0.080-0.256)
≥7.5%	76	118	194 (60.6)
Column total	183 (57.2)	137 (42.8)
Nonevent (n =4,865)
<7.5%	3,506	202	3,708 (76.2)	-0.059 (-0.075,-0.030)
≥7.5%	496	661	1,157 (23.8)
Column total	4,002 (82.3)	863 (17.7)
Total NRI for CAC				0.119 (0.080-0.256)
cPCE + hsCRP
Event (n = 320)
<7.5%	165	9	174 (54.4)	0.028 (-0.013-0.077)
≥7.5%	18	128	146 (45.6)
Column total	183 (57.2)	137 (42.8)
Nonevent (n =4,865)
<7.5%	3,882	98	3,980 (81.8)	-0.005 (-0.015-0.003)
≥7.5%	120	765	885(18.2)
Column total	4,002 (82.3)	863(17.7)
Total NRI for hsCRP				0.024 (-0.015-0.067)
cPCE + FH
Event (n = 320)
<7.5%	153	12	175 (54.6)	0.056 (0.007-0.118)
≥7.5%	30	125	155 (48.4)
Column total	183(57.2)	137(42.8)
Nonevent (n =4,865)
<7.5%	3,832	140	3,972 (81.6)	-0.006 (-0.019-0.003)
≥7.5%	170	723	893 (18.4)
Column total	4,002 (82.3)	863 (17.7)
Total NRI for FH				0.051 (0.000-0.109)
cPCE + ABI
Event (n = 320)
<7.5%	166	13	179 (55.9)	0.013 (-0.034-0.051)
≥7.5%	17	124	141 (44.1)
Column total	183 (57.2)	137 (42.8)
Nonevent (n =4,865)
<7.5%	3,910	113	4,023 (82.7)	0.004 (-0.004-0.011)
≥7.5%	92	750	842 (17.3)
Column total	4,002 (82.3)	863 (17.7)
Total NRI for ABI				0.017 (-0.031-0.058)

Values are n or n (%) unless otherwise indicated.

NRI = net reclassification improvement; other abbreviations as in Tables 1 and 2.