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. Author manuscript; available in PMC: 2017 Jan 15.
Published in final edited form as: Vet Parasitol. 2015 Nov 5;215:22–28. doi: 10.1016/j.vetpar.2015.10.023

Figure 3.

Figure 3

Babesia bovis successfully re-invaded uninfected erythrocytes upon the removal of bumped kinase inhibitor’s effect. Merozoites from the RM-1-152-treated (A) and no treatment (NT) (B) groups were freed by erythrocyte lysis. (C) and (D) correspond to merozoites-infected erythrocytes previously exposed to RM-1-152 in the presence (C) and absence (D) of 30 μM RM-1-152 at 72h, respectively while (E) and (F) correspond to NT-merozoites reinvaded erythrocytes in the presence and absence of 30 μM RM-1-152 at 72h, respectively. Comparison of B. bovis-infected erythrocytes using quantitative RT-PCR amplifying (G) BBOV_II004820 and (H) BBOV_II001650 transcripts in four treatment groups at 144h. No treatment, NT control; BKI, RM-1-152 at 30 μM; CL, 20 μM clindamycin hydrochloride and ID, 20 μM imidocarb dipropionate. *, statistically significant with p<.05.