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. Author manuscript; available in PMC: 2017 Jan 15.
Published in final edited form as: Vet Parasitol. 2015 Nov 5;215:22–28. doi: 10.1016/j.vetpar.2015.10.023

Table 1.

Putative bumped kinase inhibitor targets in Babesia microti and orthologous proteins in B. bovis based on conserved ATP-binding domain. Gatekeeper residue and putative function for each protein is also shown.

B. microti gatekeeper annotation B. bovis gatekeeper annotation
CCF74481 Thr131 CDPK-like BBOV_IV003210 Thr141 CDPK4
CCF74596 Val183 CDPK-like BBOV_II007640 Met219 CDPK, putative
CCF75526 Thr87 AMP-dependent PK BBOV_III009120 Met119 PK containing domain
CCF75730 Thr133 cAMP-dependent PK BBOV_III005470 Met374 PK containing domain
CCF75355 Thr623 cGMP-dependent PK BBOV_I004690 Thr654 cGMP-dependent PK
CCF75428 Ala163 Ser/Thr kinase BBOV_III007550 Thr155 PK containing domain
CCF75969 Met131 Ser/Thr kinase BBOV_II000760 Ser460 PK containing domain

PK, protein kinase; Thr, threonine, Ser, serine; Val, valine; Met, methionine; Ala, alanine