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. 2016 Jan 22;7:15. doi: 10.1186/s13287-016-0276-5

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© Loi et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Transient M1 macrophage-driven inflammation is a crucial step for osteogenesis by osteoprogenitors (OPs). Delayed (72 hours) phenotypical modulation of M1 macrophages into mM2 macrophages by IL-4 therapy improves osteogenesis by OPs. mM2 M2 macrophages modulated from M1 phenotype