Fig. 2.

Protective effect of FNP on lung, ileum and colon in LPS-stimulated mice. Notes: The mice in the LPS group were injected intraperitoneally with 17 mg/kg (body weight) of LPS, while control group were injected with PBS (10 mL/kg). FNP50, FNP100 and FNP200 group were orally administrated with diverse dose FNP (50 mg/kg, 100 mg/kg and 200 mg/kg) for 3 days before instillation of LPS. Histopathological studies by light microscope showing morphologically normal lung, ileum and colon tissues from mice in the control group (a, d and g). Incrassation of alveolar wall, serous exudation, hemorrhage and infiltration of PMN in lung from LPS-treated group (b) and no serous exudation or hemorrhage and less incrassation of alveolar wall and infiltration by PMN in lung from LPS-treated mice treated with FNP (c). Necrosis of epithelial cell, disorder of epithelial cell arrangement and fall of epithelium of intestinal villus in ileum and colon from LPS-treated group (e and h) and less necrosis of epithelial cell in ileum and colon from LPS-treated mice treated with FNP (f and i). Tissue sections were stained with hematoxylin and eosin and view by light microscopy (200 and 400×)