Table 3.

Hardy-Weinberg equilibrium (HWE) test and effect allele frequency (EAF) in Chinese children for32 GWA studies -derived SNPs

SNP	Nearest gene	Chr	Position	Allele		HWE P-valuea	EAFb	EAFc	F ST
				Effect	Other
Speliotes et al. 2010 (in children and adults of European ancestry) [4]
rs1558902	FTO	16	52361075	A	T	0.58	0.13	0.42	0.105e
rs2867125	TMEM18	2	612827	C	T	0.20	0.91	0.83	0.014
rs571312	MC4R	18	55990749	A	C	0.67	0.23	0.24	0.000
rs10938397	GNPDA2	4	44877284	G	A	0.54	0.31	0.43	0.015
rs10767664	BDNF	11	27682562	A	T	0.30	0.55	0.78	0.059
rs2815752	NEGR1	1	72585028	A	G	0.97	0.92	0.61	0.134e
rs7359397	SH2B1	16	28793160	T	C	0.17	0.16	0.40	0.071
rs9816226	ETV5	3	187317193	T	A	0.36	0.97	0.82	0.060
rs3817334	MTCH2	11	47607569	T	C	0.16	0.33	0.41	0.007
rs29942d	KCTD15	19	39001117	C	T	0.76	0.25	0.31	0.004
rs543874	SEC16B	1	176156103	G	A	0.80	0.22	0.19	0.001
rs987237	TFAP2B	6	50911009	G	A	0.52	0.18	0.18	0.000
rs7138803	FAIM2	12	48533735	A	G	0.01	0.28	0.38	0.011
rs713586	RBJ	2	25011512	C	T	0.77	0.49	0.47	0.000
rs2241423	MAP2K5	15	65873892	G	A	0.67	0.41	0.78	0.142e
rs2287019	QPCTL	19	50894012	C	T	0.09	0.82	0.80	0.001
rs1514175	TNNI3K	1	74764232	A	G	0.91	0.78	0.43	0.128e
rs2112347	FLJ35779	5	75050998	T	G	0.88	0.44	0.63	0.036
rs16912921d	LRRN6C	9	28403461	A	C	0.19	0.30	0.34	0.002
rs3810291	TMEM160	19	52260843	A	G	0.58	0.29	0.67	0.145e
rs1555543	PTBP2	1	96717385	C	A	0.81	0.87	0.59	0.099
rs9579083d	MTIF3	13	26915270	C	G	0.87	0.15	0.23	0.010
rs4929949	RPL27A	11	8561169	C	T	0.79	0.40	0.52	0.014
rs206936	NUDT3	6	34410847	G	A	0.30	0.51	0.21	0.098
Scherag et al. 2010 (in children and adults of European ancestry) [6]
rs12145833	SDCCAG8	1	241550377	T	G	0.55	0.91	0.87	0.004
rs13278851	TNKS/MSRA	8	9788282	A	G	0.28	0.14	0.11	0.002
Bradfield et al. 2012 (in children of European ancestry) [5]
rs9568856	OLFM4	13	52962982	A	G	0.34	0.33	0.16	0.039
rs9299	HOXB5	17	44024429	A	G	0.44	0.53	0.65	0.015
Okada et al. 2012 (in East Asians) [7]
rs2206734	CDKAL1	6	20802863	G	A	0.66	0.59	0.59	0.000
rs11142387	KLF9	9	72188152	C	A	0.96	0.33	0.46	0.018
Wen et al. 2012 (in East Asians) [8]
rs261966d	PCSK1	5	95875343	G	A	0.53	0.45	0.42	0.001
rs12597579	GP2	16	20165368	C	T	0.99	0.73	0.80	0.007

Chr Chromosome; Position: NCBI build 36.3 (NCBI, Bethesda, MD); EAF Effect allele frequency, HWE Hardy-Weinberg equilibrium

^aHWE P-value in normal-weight Chinese children

^bEffect allele frequency in all genotyped individuals of the present study

^cEffect allele frequency of SNPs in the discovery studies (Ref. [4-8]), and that of each proxy SNP is from NCBI database among the same populations that in the discovery study

^dProxy SNPs were used in the present study to replace the SNPs from the discovery studies

^e F _ST > 0.10 as indicator of large genetic differentiation between population in the present study and that in the discovery study