Table 1.
Summary of tissue specimens and patient data
| Pilocytic Astrocytoma WHO°I | Diffuse Astrocytoma WHO°II | Anaplastic Astrocytoma WHO°III | Glioblastoma WHO°IV | Infiltration Zone of Glioblastoma | Surrounding Normal- appearing White Matter | Surrounding Normal-appearing Gray Matter | |
|---|---|---|---|---|---|---|---|
| Male/female | 17/30 | 10/6 | 20/15 | 143/109 | 23/16 | 9/10 | 32/30 |
| Median age (range), y | 14.0 (0–75) | 30.5 (5–52) | 43 (22–66) | 61 (7–80) | 61 (8–79) | 63 (8–78) | 61 (30–78) |
| Specimens (n) | 47 | 16 | 35 | 252 | 39 | 19 | 62 |
| Tumor localization (supratentorial/infratentorial) | 31/16 | 16/0 | 34/1 | 250/2 | 39/0 | 19/0 | 60/0 |
| Median follow-up (range), mo | 31.0 (0.0–142.1) | 52.9 (0.0–122.1) | 12.1 (0.0–164.3) | 11.3 (0.0–94.0) | 5.9 (0.0–47.8) | 6.8 (0.0–34.6) | 9.1 (0.0–104.7) |
| mIDH1 (R132H) (mut/wt) | 0/46 | 8/6 | 19/16 | 10/242 | 1/38 | 1/18 | 5/55 |
| Ki67 index (mean, 95% CI) | 2.7% (1.7–3.8) | 0.9% (0.2–1.5) | 6.3% (3.6–8.8) | 13.0% (11.6–14.3) | 6.6% (4.9–8.4) | 1.4% (0.2–2.6) | 1.5% (0.6–2.4) |
Abbreviations: CI, confidence interval; mo, months; n, number; y, years.