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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: J Cell Physiol. 2015 Aug;230(8):1944–1953. doi: 10.1002/jcp.24929

Figure 5. Alendronate increases bone stiffness while diabetes and alendronate reduce force to fracture.

Figure 5

Three-point bending tests were performed on femurs from control (white bars) and diabetic (black bars) non-treated and alendronate treated mice. Stiffness, ultimate stress, energy and work to fracture (area under the stress strain curve) were calculated and represented as average value ± SE (n≥7–8 per group). Work to fracture was analyzed by 2-way ANOVA to determine the effects of bisphosphonate treatment, diabetes and bisphosphonate treatment × diabetes on femur strength parameters. Fisher post hoc test was used to compare differences between groups. The rest of the graphs were analyzed by one-way ANOVA followed by Fisher post hoc tests to compare differences between groups, *p<0.05, **p<0.01.