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. Author manuscript; available in PMC: 2016 Jan 23.
Published in final edited form as: Epidemiology. 2013 Jul;24(4):569–576. doi: 10.1097/EDE.0b013e31829443ee

TABLE 2.

Predicted Percentage Decrease (95% CI) in Each Serum Lipid per Halving PFOA or PFOS in Serum

Predictor Response Model 1a Model 2b Model 3c Model 2 R2 Model 2 Partial R2d
PFOA LDL cholesterol   3.08 (0.98 to 5.14)   3.58 (1.47 to 5.66)   2.92 (0.71 to 5.09) 0.06 0.02
Total cholesterol   1.31 (0.01 to 2.60)   1.65 (0.32 to 2.97)   0.63 (−0.88 to 2.12) 0.03 0.01
HDL cholesterol   0.91 (−0.61 to 2.41)   1.33 (−0.21 to 2.85)   1.24 (−0.34 to 2.79) 0.04 0.005
Triglycerides −0.86 (−5.44 to 3.52) −0.78 (−5.34 to 3.58) −1.16 (−5.85 to 3.33) 0.08 0.0002
PFOS LDL cholesterol   4.58 (2.12 to 6.97)   4.99 (2.46 to 7.44)   4.59 (1.97 to 7.14) 0.07 0.03
Total cholesterol   2.75 (1.22 to 4.25)   3.20 (1.63 to 4.76)   3.21 (1.59 to 4.81) 0.04 0.03
HDL cholesterol   0.87 (−0.95 to 2.66)   1.28 (−0.59 to 3.12)   0.82 (−1.11 to 2.70) 0.04 0.003
Triglycerides   2.12 (−3.23 to 7.19)   2.49 (−2.88 to 7.57)   3.24 (−2.2 to 8.42) 0.08 0.001
a

Model 1 is unadjusted.

b

Model 2 is adjusted for age, sex, interval between measurements, and fasting status.

c

Model 3 is joint model for PFOA with PFOS as a spline smooth or vice versa. Models are also adjusted for age, sex, interval, and fasting status.

d

Partial R2 is for the change in PFOA or PFOS.