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. Author manuscript; available in PMC: 2017 Jan 27.
Published in final edited form as: Eur J Med Chem. 2015 Dec 15;108:505–528. doi: 10.1016/j.ejmech.2015.12.018

Scheme 1. Syntheses of intermediate chemicals 46, 47, 48, and 11.

Scheme 1

Reagents and conditions: (a) ethyl chloroformate, EtOH, 5°C to 7°C; (b): Na2CO3/H2O, 2 h; (c): 2-chloroacetyl chloride, anhydrous toluene, reflux, 1 h; (d): Et2NH, anhydrous toluene, reflux, 4 h.