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. Author manuscript; available in PMC: 2017 Jan 27.
Published in final edited form as: Eur J Med Chem. 2015 Dec 15;108:505–528. doi: 10.1016/j.ejmech.2015.12.018

Scheme 2. Syntheses of CINAP1 analog compounds 22 to 32.

Scheme 2

Reagents and conditions: (a) R1H, NaH, DMF, microwave, 80°C, 0.5 h; (b): R1H, NaH, DMF, 0°C, 1.5 h; (c): NaI, acetone, N2, 25°C, 12 h; (d): 2,2,6,6-tetramethylpiperidine, toluene, 120°C, 16 h; (e): NH3.H2O, MeOH, 120°C, 12 h; (f): furan-2,5-dione, AcOH, 100°C, 12 h.

*This intermediate chemical was prepared (purified or unpurified) and used as raw starting material for the next step without structural characterization.