Table 2.
Number of seizures counted by blinded observers during asynchronous stimulation protocols (continuous and intermitted; theta peak and theta range) in PRE-STIM, STIM and POST-STIM epochs.
| (A) Asynchronous continuous theta peak (7.7 Hz) pulse stimulation | ||||
|---|---|---|---|---|
| (A1) Raw number of seizures with asynchronous continuous theta peak (7.7 Hz) pulse stimulation: | ||||
| Session number with this protocol |
Rat number (Rat ID) From table 1 |
PRE-STIM (raw number of seizures in 1 hour) |
STIM (raw number of seizures in 1 hour) |
POST-STIM (raw number of seizures in 1 hour) |
| 1 | 1(TTMEA1) | 2 | 1 | 4 |
| 2 | 1(TTMEA1) | 5 | 2 | 5 |
| 3 | 2(TTMEA2) | 3 | 2 | 3 |
| 4 | 3(TTMEA3) | 2 | 2 | 5 |
| 5 | 4(TTMEA4) | 2 | 0 | 2 |
| 6 | 5(TTMEA5) | 5 | 3 | 5 |
| Mean±std | 3.17±1.47 | 1.67±1.03 | 4±01.26 | |
| (A2) Number of seizures normalized w.r.t. seizures in baseline (PRE-STIM) with asynchronous continuous theta peak (7.7 Hz) pulse stimulation: | ||||
|---|---|---|---|---|
| Sessions number with this potocol |
Rat number (Rat ID) From table 1 |
PRE-STIM (normalized number of seizures in 1 hour) |
STIM (normalized number of seizures in 1 hour) |
POST-STIM (normalized number of seizures in 1 hour) |
| 1 | 1(TTMEA1) | 1 | 0.5 | 2 |
| 2 | 1(TTMEA1) | 1 | 0.4 | 1 |
| 3 | 2(TTMEA2) | 1 | 0.67 | 1 |
| 4 | 3(TTMEA3) | 1 | 1 | 2.5 |
| 5 | 4(TTMEA4) | 1 | 0 | 1 |
| 6 | 5(TTMEA5) | 1 | 0.6 | 1 |
| Mean±std | 1±0 | 0.53±0.33 | 1.42±0.66 | |
| %change in mean seizures compared to baseline | 0% | −47% | +42% | |
| (B) Asynchronous intermittent theta peak (7.7 Hz) pulse stimulation | ||||
|---|---|---|---|---|
| (B1) Raw number of seizures with asynchronous intermittent theta peak (7.7 Hz) pulse stimulation: | ||||
| Session Number with this protocol |
Rat number (Rat ID) From table 1 |
PRE-STIM (raw number of seizures in 1 hour) |
STIM (raw number of seizures in 1 hour) |
POST-STIM (raw number of seizures in 1 hour) |
| 1 | 1(TTMEA1) | 2 | 2 | 2 |
| 2 | 2(TTMEA2) | 3 | 1 | 2 |
| 3 | 2(TTMEA2) | 2 | 1 | 1 |
| 4 | 6(TTMEA6) | 3 | 2 | 3 |
| 5 | 1(TTMEA1) | 1 | 0 | 2 |
| 6 | 4(TTMEA4) | 2 | 1 | 2 |
| Mean±std | 2.17±0.75 | 1.17±0.75 | 2±0.63 | |
| (B2) Number of seizures normalized w.r.t. seizures in baseline (PRE-STIM) with asynchronous intermittent theta peak (7.7 Hz) pulse stimulation: | ||||
|---|---|---|---|---|
| Sessions number with this potocol |
Rat number (Rat ID) From table 1 |
PRE-STIM (normalized number of seizures in 1 hour) |
STIM (normalized number of seizures in 1 hour) |
POST-STIM (normalized number of seizures in 1 hour) |
| 1 | 1 (TTMEA1) | 1 | 1 | 1 |
| 2 | 2 (TTMEA2) | 1 | 0.33 | 0.67 |
| 3 | 2 (TTMEA2) | 1 | 0.5 | 0.5 |
| 4 | 6 (TTMEA6) | 1 | 0 | 2 |
| 5 | 1 (TTMEA1) | 1 | 0.67 | 1 |
| 6 | 4 (TTMEA4) | 1 | 0.5 | 1 |
| Mean±std | 1.0±0 | 0.5±0.33 | 1.03±0.52 | |
| %change in mean seizures compared to baseline | 0% | −50% | +3% | |
| (C) Asynchronous intermittent theta range (6–12 Hz) pulse stimulation | ||||
|---|---|---|---|---|
| (C1) Raw number of seizures with asynchronous continuous theta range (6–12 Hz) pulse stimulation: | ||||
| Session Number with this protocol |
Rat number (Rat ID) From table 1 |
PRE-STIM (raw number of seizures in 1 hour) |
STIM (raw number of seizures in 1 hour) |
POST-STIM (raw number of seizures in 1 hour) |
| 1 | 7 (TTMEA7) | 2 | 1 | 2 |
| 2 | 7 (TTMEA7) | 2 | 1 | 3 |
| 3 | 8 (TTMEA8) | 2 | 1 | 1 |
| 4 | 9 (TTMEA9) | 1 | 1 | 1 |
| 5 | 9 (TTMEA9) | 2 | 1 | 3 |
| Mean±std | 1.8±0.44 | 1±0 | 2±1 | |
| (C2) Number of seizures normalized w.r.t. seizures in baseline (PRE-STIM) with asynchronous continuous theta peak (7.7 Hz) pulse stimulation: | ||||
|---|---|---|---|---|
| Sessions number with this potocol |
Rat number (Rat ID) From table 1 |
PRE-STIM (normalized number of seizures in 1 hour) |
STIM (normalized number of seizures in 1 hour) |
POST-STIM (normalized number of seizures in 1 hour) |
| 1 | 7 (TTMEA7) | 1 | 0.5 | 1 |
| 2 | 7 (TTMEA7) | 1 | 0.5 | 1.5 |
| 3 | 8 (TTMEA8) | 1 | 0.5 | 0.5 |
| 4 | 9 (TTMEA9) | 1 | 1 | 1 |
| 5 | 9 (TTMEA9) | 1 | 0.5 | 1.5 |
| Mean±std | 1.0±0 | 0.6±0.22 | 1.1±0.42 | |
| %change in mean seizures compared to baseline | 0% | −40% | 10% | |
| (D) Asynchronous intermittent theta range (6–12 Hz) pulse stimulation | ||||
|---|---|---|---|---|
| (D1) Raw number of seizures with asynchronous intermittent theta range (6–12 Hz) pulse stimulation: | ||||
| Session Number with this protocol |
Rat number (Rat ID) From table 1 |
PRE-STIM (raw number of seizures in 1 hour) |
STIM (raw number of seizures in 1 hour) |
POST-STIM (raw number of seizures in 1 hour) |
| 1 | 9 (TTMEA9) | 1 | 1 | 2 |
| 2 | 8 (TTMEA8) | 2 | 1 | 2 |
| 3 | 10 (TTMEA10) | 2 | 1.5* | 1.5* |
| 4 | 11 (TTMEA11) | 1 | 0 | 1 |
| 5 | 12 (TTMEA12) | 2 | 1 | 3 |
| Mean±std | 1.6±0.55 | 0.9±0.55 | 1.9±0.74 | |
| (D2) Number of seizures normalized w.r.t. seizures in baseline (PRE-STIM) with asynchronous intermittent theta peak (6–12 Hz) pulse stimulation: | ||||
|---|---|---|---|---|
| Sessions number with this potocol |
Rat number (Rat ID) From table 1 |
PRE-STIM (normalized number of seizures in 1 hour) |
STIM (normalized number of seizures in 1 hour) |
POST-STIM (normalized number of seizures in 1 hour) |
| 1 | 9 (TTMEA9) | 1 | 1 | 2 |
| 2 | 8 (TTMEA8) | 1 | 0.5 | 1 |
| 3 | 10 (TTMEA10) | 1 | 0.75 | 0.75 |
| 4 | 11 (TTMEA11) | 1 | 0 | 1 |
| 5 | 12 (TTMEA12) | 1 | 0.5 | 1.5 |
| Mean±std | 1.0±0 | 0.55±0.37 | 1.25±0.5 | |
| %change in mean seizures compared to baseline | 0% | −45% | 25% | |
*
Average was taken to resolve disagreement in seizure counts between two blinded observers.