TABLE III.

Effect of sensorineural hearing loss on intelligence and neurocognitive function

Predictor	Neurocognitive Measure1
	FSIQ	VCI2	PRI	PSI	WMI
	Coeff [95%CI]	Coeff [95%CI]	Coeff [95%CI]	Coeff [95%CI]	Coeff [95%CI]
Age at diagnosis (yrs)	−0.84 [−2.03,0.35]	−0.25 [−1.43,0.94]	−0.67 [−1.91, 0.58]	−0.28 [−1.88, 1.32]	−0.36 [−1.46, 0.75]
Underwent SCT	12.85 [−0.03,25.73]	6.63 [−6.41,19.68]	5.62 [−6.62,17.85]	24.19 [7.03, 41.36]**	13.71 [0.80, 26.61]*
Presence of PFS	5.09 [−3.48,13.66]	2.65 [−7.22,12.52]	2.42 [−6.27,11.11]	−0.78 [−12.93,11.37]	−7.80 [−15.75, 0.15]
Radiation Therapy
Dose to WB (cGy)	−0.02 [−0.31,0.27]	−0.02 [−0.31,0.27]	0.03 [−0.27, 0.32]	0.26 [−0.18, 0.71]	0.42 [0.10, 0.74]*
Dose to PF (cGy)	−0.06 [−0.34,0.21]	−0.22 [−0.50,0.05]	−0.08 [−0.35, 0.18]	−0.09 [−0.28, 0.47]	0.27 [−0.02, 0.56]
Presence of Hearing Loss3	−16.14 [−25.66,−6.63]†	−13.19 [−23.04,−3.34]**	−16.09 [−25.93,−6.26]**	−15.41 [−29.02, −1.81]*	−17.10 [−25.76, −8.43]†
Intercept	99.61 [80.94,118.28]	98.31 [78.86,117.75]	105.57 [86.85,124.30]	77.73 [70.39, 112.87]	83.81 [63.59, 104.02]

¹Individual hierarchical linear regression models constructed for each neurocognitive measure, significance set at α<0.05 (bolded). See statistical methods for additional details.

²Model additionally includes ethnicity and diagnosis ³Significant hearing loss defined as Chang Grade ≥2b.

95%CI=95% Confidence Interval, SCT=hematopoietic stem cell transplant, PFS=posterior fossa syndrome, WB=Whole Brain, PF=Additive dose to posterior fossa. IQ = Intelligence Quotient. VCI = Verbal Comprehension Index. PRI = Perceptual Reasoning Index/Performance IQ. WMI = Working Memory Index. PSI – Processing Speed Index. VMI = Visual-Motor Integration score.

^*p<0.05,

^**p≤0.010,

^†p≤0.001.