TABLE I.
Brain Region | a Specific Binding [125I]E-IA-DM-PE-PIPZE (fmol/mg tissue) | b Specific Binding [3H](+)-NANM (fmol/mg tissue) | |
---|---|---|---|
Control | (−)-Cocaine | ||
Cortex | |||
Cingulate | 2.69 ± 0.20 | 1.36 ± 0.14 | 7.3 ± 0.9 |
Frontal | 2.99 ± 0.19 | 1.58 ± 0.14 | 7.3 ± 0.9 |
Parietal | 3.12 ± 0.14 | 1.41 ± 0.13 | 8.6 ± 0.7 |
Temporal | 2.93 ± 0.16 | 1.43 ± 0.14 | 7.5 ± 1.7 |
Entorhinal | 2.52 ± 0.09 | 1.10 ± 0.11 | 5.3 ± 1.0 |
Caudate-putamen | 1.96 ± 0.07 | 0.87 ± 0.09 | 5.0 ± 0.5 |
Hippocampus | |||
CA1 pyramidal | 2.25 ± 0.12 | 1.04 ± 0.09 | 3.8 ± 1.1 |
CA2 pyramidal | 2.87 ± 0.13 | 1.41 ± 0.11 | 5.1 ± 1.4 |
CA3 pyramidal | 3.34 ± 0.10 | 1.50 ± 0.12 | 9.3 ± 1.5 |
Dentate Gyrus | 3.27 ± 0.08 | 1.39 ± 0.09 | 8.2 ± 2.0 |
Nonpyramidal | 1.84 ± 0.08 | 0.63 ± 0.09 | 2.2 ± 0.8 |
Diencephalon | |||
Thalamus | 2.57 ± 0.13 | 1.52 ± 0.18 | 8.0 ± 0.6 |
Thalamic nuclei | 2.94 ± 0.10 | 1.60 ± 0.25 | |
Mesencephalon | |||
Periaqueductal Gray | 4.07 ± 0.13 | 1.78 ± 0.16 | 11.4 ± 0.8 |
Superior Colliculi | 3.50 ± 0.14 | 1.59 ± 0.11 | |
Inferior Colliculi | 3.50 ± 0.20 | 1.69 ± 0.16 | |
Metencephalon | |||
Cerebellum (whole) | 3.18 ± 0.08 | 1.32 ± 0.14 | 10.7 ± 0.7 |
Molecular layer | 2.38 ± 0.08 | 1.08 ± 0.08 | |
Granular layer | 4.13 ± 0.20 | 1.90 ± 0.15 | |
White Matter | |||
Corpus callosum | 1.99 ± 0.06 | 1.29 ± 0.17 | 2.2 ± 0.5 |
Values are means ± SEM, n = 4 – 6 from horizontal sections.
[3H](+)-NANM data from Bouchard et al., 1996.