Table 1.
Descriptive statistics and GRS regression summaries for PD, SWEDD and healthy controls.
| Part A. Descriptive statistics | |||||
| Subset | PD | SWEDD | Controls | ||
| Total in analyses (N) | 367 | 55 | 165 | ||
| Age in years (mean, SD) | 64.256, 9.598 |
63.018, 10.117 | 63.794, 1.588 | ||
| Females (%) | 33.242 | 34.545 | 33.333 | ||
| Family history of PD (%) | 25.068 | 30.909 | 5.454 | ||
| N370S carriers (%) | 1.912* | 1.818 | 0.606 | ||
| G2019S carriers (%) | 1.3624 | 0 | 0 | ||
| SNCA multiplication (%) | 0 | 1 | 0 | ||
| Common variant GRS (mean, SD in Z units) |
0.511, 1.034 | 0.323, 0.976 | 0, 1 | ||
| Common and rare variant GRS (mean, SD in Z units) |
0.596, 1.201 | 0.347, 1.065 | 0, 1 | ||
|
Part B. GRS logistic regression
models |
|||||
| Subset | Odds ratio of trend |
95% confidence interval |
P-value of trend |
AUC | AUC confidence interval |
| PD versus controls, common variant GRS |
1.691 | 1.372, 2.083 | 8.39E-07 | 0.741 | 0.698-0.784 |
| SWEDD versus controls, common variant GRS |
1.371 | 0.971, 1.934 | 0.073 | 0.696 | 0.608-0.784 |
| PD and SWEDD versus controls, common variant GRS |
1.617 | 1.328, 1.969 | 1.69E-06 | 0.716 | 0.674-0.759 |
| PD versus controls, common and rare variant GRS |
1.736 | 1.413, 2.134 | 1.59E-07 | 0.748 | 0.706-0.791 |
| SWEDD versus controls, common and rare variant GRS |
1.359 | 0.970, 1.904 | 0.075 | 0.694 | 0.606-0.782 |
| PD and SWEDD versus controls, common and rare variant GRS |
1.701 | 1.396, 2.074 | 1.40E-07 | 0.733 | 0.691-0.775 |
Star denotes one missing genotype. Odds ratios and other summary statistics are based on a single standard deviation (Z) change in the GRS distribution from the mean of the healthy controls. Age refers to onset in cases and age at last clinic visit in controls. Family history refers to any first or second degree relatives with PD from self-report.