Table 3.

Inhibition Data for Monoaryl Hydroxylamines with Ring Substitution^a

Compd	X	IC50(μM)	Compd	X	IC50(μM)	Compd	X	IC50(μM)
8	4-I	0.22± 0.066	16	3-F	1.0	24	2-OCH3	5.4
9	3-Cl	0.30± 0.015	17	4-Cl	1.3	25	4-CF3	8.9
10	3-Br	0.32± 0.042	18	2-F	1.4	26	3-OCH3	9.5
11	3-I	0.34± 0.12	19	4-Br	1.6	27	4-Ph	12
12	3-CF3	0.41	20	2-Br	1.6	28	4- CH(CH3)2	15
13	2-I	0.57	21	2-CF3	2.5	29	2-OH	19
14	2-Cl	0.63	22	3-CH3	2.7	30	4-OCH3	24
Lead	H	0.81±0.081	23	4-NO2	2.7	31	4-OH	61
15	4-F	0.98

^aIC₅₀ values are based on single point inhibition curves run once for each compound, but repeated at least 2x for the most potent compounds (initial IC₅₀ values below 0.4 μM). These results are reported as the averages ± SD.