Table 2.
Weighted analysis for RCC risk and occupational sunlight exposure, stratified by race
| ALL | WHITES | BLACKS | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | Cases | Controls | Cases | Controls | ||||||||
| Sunlight | N (%a) | N (%a) | OR (95%CI) | P-trendb | N (%a) | N (%a) | OR (95%CI) | P-trendb | N (%a) | N (%a) | OR (95%CI) | P-trendb | lrt |
| Cumulative Exposure (low exposure-unit years) | |||||||||||||
| <4.19 | 315 (24.8) | 301 (21.8) | 1.00 [Ref] | 227 (24.3) | 156 (21.5) | 1.00 [Ref] | 88 (26.5) | 145 (22.8) | 1.00 [Ref] | ||||
| ≥4.19-<6.30 | 281 (23.0) | 300 (24.1) | 0.80 (0.61 to 1.06) | 191 (21.7) | 163 (23.4) | 0.78 (0.57 to 1.07) | 90 (26.8) | 137 (26.0) | 0.88 (0.55 to 1.42) | ||||
| ≥6.30-<9.00 | 262 (23.2) | 303 (26.5) | 0.67 (0.50 to 0.90) | 194 (24.3) | 192 (27.5) | 0.69 (0.49 to 0.97) | 68 (20.0) | 111 (23.4) | 0.65 (0.38 to 1.12) | ||||
| ≥9 .00 | 321 (29.0) | 301 (27.7) | 0.74 (0.56 to 0.99) | 228 (29.8) | 186 (27.7) | 0.78 (0.54 to 1.11) | 93 (26.7) | 115 (27.7) | 0.68 (0.42 to 1.11) | ||||
| 0.03 | 0.20 | 0.07 | 0.83 | ||||||||||
| Frequency-Adjusted Duration of Exposure (years) | |||||||||||||
| <4.17 | 315 (24.8) | 301 (21.7) | 1.00 [Ref] | 227 (24.3) | 156 (21.3) | 1.00 [Ref] | 88 (26.5) | 145 (22.7) | 1.00 [Ref] | ||||
| ≥4.17-<6.24 | 285 (23.2) | 302 (24.1) | 0.80 (0.61 to 1.06) | 194 (22.0) | 161 (23.1) | 0.79 (0.58 to 1.08) | 91 (26.8) | 141 (27.1) | 0.85 (0.54 to 1.35) | ||||
| ≥6.24-<8.68 | 263 (23.5) | 301 (26.1) | 0.66 (0.49 to 0.89) | 193 (24.4) | 188 (27.0) | 0.67 (0.48 to 0.94) | 70 (20.9) | 113 (23.6) | 0.68 (0.40 to 1.16) | ||||
| ≥8.68 | 316 (28.5) | 301 (28.1) | 0.70 (0.52 to 0.94) | 226 (29.3) | 192 (28.7) | 0.70 (0.48 to 1.03) | 90 (25.9) | 109 (26.6) | 0.69 (0.42 to 1.13) | ||||
| 0.01 | 0.07 | 0.09 | 0.81 | ||||||||||
| Frequency-Adjusted Duration of Exposure Among Only Low Intensity Jobs (years) | |||||||||||||
| <4.17 | 309 (28.7) | 294 (24.1) | 1.00 [Ref] | 222 (28.0) | 152 (23.5) | 1.00 [Ref] | 87 (30.6) | 142 (25.8) | 1.00 [Ref] | ||||
| ≥4.17-<6.24 | 273 (26.3) | 286 (26.0) | 0.81 (0.61 to 1.07) | 186 (25.0) | 154 (24.8) | 0.80 (0.58 to 1.10) | 87 (29.9) | 132 (29.6) | 0.86 (0.53 to 1.39) | ||||
| ≥6.24-<8.68 | 235 (24.9) | 274 (27.1) | 0.63 (0.47 to 0.86) | 174 (26.1) | 175 (28.1) | 0.64 (0.45 to 0.90) | 61 (21.4) | 99 (24.0) | 0.65 (0.38 to 1.10) | ||||
| ≥8.68 | 188 (20.2) | 212 (22.9) | 0.56 (0.40 to 0.79) | 135 (20.9) | 141 (23.7) | 0.55 (0.36 to 0.85) | 53 (18.1) | 71 (20.6) | 0.60 (0.34 to 1.05) | ||||
| 0.0003 | 0.004 | 0.04 | 0.54 | ||||||||||
| Frequency-Adjusted Duration of Exposure Among Any High Intensity Jobs (years) | |||||||||||||
| <8.68 | 46 (25.4) | 50 (30.6) | 1.00 [Ref] | 32 (24.9) | 24 (27.9) | 1.00 [Ref] | 14 (27.2) | 26 (36.2) | 1.00 [Ref] | ||||
| ≥8.68 | 128 (74.6) | 89 (69.4) | 1.23 (0.72 to 2.11) | 91 (75.1) | 51 (72.1) | 1.06 (0.48 to 2.33) | 37 (72.8) | 38 (63.8) | 1.78 (0.57 to 5.56) | ||||
| 0.66 | |||||||||||||
Abbreviations: BMI- body mass index; CI- confidence interval; lrt- likelihood ratio test; N, number; OR- odd ratio; RCC- renal cell carcinoma; Ref- reference.
Analyses adjusted for sex, race, smoking status, age, BMI, hypertension, family history of cancer, education, center and dietary vitamin D intake.
a
A sample-weighted frequency distribution.
b
P-value from sample Wald F-test.