Table 1.

Clinicopathologic and genetic features of pedicatric oligodendrogliomas

Age/sex	Location	Grade	Prior therapy	Somatic alterations by SNP array	Possible germ line alterations by SNP array	Genes	BRAF‐KIAA1549 FISH	BRAF V600E	IDH1 (R132H) IHC	Molecular other
2/M	Frontal lobe	II	0	Normal karyotype		NA	Negative		Negative
1/M	Frontal lobe	II	0	Normal karyotype		NA	Negative	Negative (IHC)	Negative	MGMT not methylated
10/F	Frontal lobe	II	0	Normal karyotype		NA	Negative	Negative (IHC)
13/M	Frontal lobe	II	0	No somatic alterations	5q33.3, 16q24.1qtel(CNN), 20qcenq11.23(CNN)	NA			Negative
19/F	Temporal lobe	II	0	del 1p (whole arm), del 19q (whole arm)	CN‐LOH 2q33.3q35, CN‐LOH 11q22.3q22.3(CNN),	Chr 1p (FUBP1), 19q (CIC)			Positive
1/M	Parietal lobe	II	0	Normal karyotype		NA
1/M	Frontal lobe	II	0	Normal karyotype		NA
8/F	Temporal lobe	II	0	del8p23.1p23.1, del8p21.2p12, del8q13.2q13.3, del8q22.1q23.1	13q		Negative	Negative (IHC)	Negative
15/M	Temporal lobe	II	0	LOH 1q (whole arm)	22q13.1q13.2	22q (germ line XRCC6, RANGAP1, SGSM3,MKL1, ST13,DNAJB7, TEF, TOB2, NHP2L1, SREBF2, CENPM, TNFRSF13C, CYP2D6, TCF20, CYP2D7P1, RBX1, MIR4766, MIR1281, and MCHR1. )			Negative
9/F	Brain	II	0	Gain whole Chr7, LOH 9ptelp21.3, del9p21.3p21.3 (Homozygous), LOH 9p21.3p13.3	6p22.1p22.1, 6q22.2q22.31; 12p13.2p13.1, 12q23.1q23.3	Ch 7 (EGFR, MET, HGF, BRAF), 9p (CDKN2A, CDKN2B, CDKN2BAS, C9orf53, MTAP)
1/M	brainstem	II	0	chr22q13.1	5q23.3q31.2; 12q24.11q24.13	DDX17, CSNK1E, DNC1, CBY1, SUN2, CBX6, CBX7, PDGFB			Negative
2/F	Parietal lobe	II	0	Normal karyotype		NA	Negative	Negative (IHC)	Negative
16/M	Frontal lobe	II	0	del 1p (whole arm), del 19q (whole arm)		FUBP1, CIC			Negative
4/M	Medial temporal	II	0	ND		NA			Negative
14/M	Frontal lobe	II	0	del 16p13.11p12.3, LOH 17p (whole arm)		Chr 17p (TP53)
12/M	Temporal lobe	II	0	ND		NA	Negative	Negative (IHC)	Negative	Negative for 1p19q LOH (STR)
2/M	Frontal lobe	II	0	ND		NA	Negative		Negative	Negative for 1p19q LOH (STR)
16/M	Parietal lobe	II	0	ND		NA	Negative	Negative (IHC)	Positive
11/M	Posterior fossa	II	0	Gain whole Chr6, Chr7, Chr8, Chr11, Chr12		Ch 7 (EGFR, MET, HGF, BRAF), FGFR1	Negative	Negative (PCR)		Negative for 1p19q LOH (STR)
19/M	Frontal lobe	II	0	ND		NA			Negative	1p19q loss (STR)
16/M	Frontal lobe	III	0	LOH 3q12.1q26.31, LOH 3q29qtel, LOH 4p (whole arm), dup4q12q13.1, CN‐LOH 4q13.1qtel, del6ptelp21.3, del6p21.3p21.31 (small population subset), del11ptelp15.3, LOH 12q (whole arm), del13q (whole arm), CN‐LOH 17ptelp11.2, LOH 18p (whole arm), del18q (near whole arm), LOH 21q (whole arm)		Chr 11p (CDKN1C, NUP98, SLC22A18), 13q (RB1), 17p (TP53), Chr 18 (DCC)		Negative (PCR)	Negative	MGMT methylated
11/F	Frontal lobe	III	0	del 1p (whole arm), LOH 1q (whole arm), del 2 (whole Chr deletion), del 3ptelp21.1, del 3q29qtel, del6ptelp22.3, del9ptelp13.2, LOH 9q21.33qtel, del 11ptelp15.1, del 14q21.3qtel, del 15q24.3qtel, del 17ptelp11.2, CN‐LOH 17q22qtel, heterogeneous whole Ch18 loss, del 19q (whole arm), gain X (whole Chr)	22q13.1q13.2	Chr 1p (FUBP1), 11p (CDKN1C, NUP98, SLC22A18), 19q (CIC), 17p(TP53), Chr 18 (DCC), 22q(germ line XRCC6, RANGAP1, SGSM3,MKL1, ST13,DNAJB7, TEF, TOB2, NHP2L1, SREBF2, CENPM, TNFRSF13C, CYP2D6, TCF20, CYP2D7P1, RBX1, MIR4766, MIR1281, and MCHR1)
17/F	Frontal lobe	III	Chemotherapy and radiation 10 years prior for leukemia with CNS involvement	del 1p (whole arm), CN‐LOH 1qcentq25.2, del 4q21.1qtel, del 13q (whole arm), del14q23.3qtel, gain 17q23.2qtel		Chr 1p (FUBP1), Chr 13 (RB1)
3/M	cerebellum	III	RT+Chemo	del 1ptelp36.23, gain 1p36.23p36.13, gain 1p36.12p36.11, del 1p36.11cent, del 2q22.3p23.1, del 3q26.32qtel, del 6q23.3q25.1, del 8ptelp23.2, del 9ptelp13.1, del 10q26.3qtel, del 11p15.4p11.2, gain 12q12q13.11, gain 12q13.13q13.2, gain 12q13.2q13.3, gain 12q14.1q15, del 16q12.1qtel, del 19q12q13.11, del 19q13.13qtel, del 20p (whole arm)		12q (CDK4, MDM2)			Negative
10/F	Parietal lobe	III	0	del17qcentq21.33, CN‐LOH 17q22q24.2(CNN), del17q24.3qtel		NF1	Negative		Negative
18/F	Frontal lobe	III	0	ND		NA	Negative		Positive	1p19q loss (STR)
7/M	Frontal lobe	III	0	ND		NA	Negative		Negative	Negative for 1p19q LOH (STR)
11/M	Occipital lobe	III	0	ND		NA	Negative		Negative	Negative for 1p19q LOH (STR)