Table 3.
Associations of the rs9829896 minor allele (C) with specific drugs, using separate logistic regression models, in African Americans from the Urban Health Study (UHS) and the Genetic Association Information Network (GAIN).
| Specific drug | UHS | GAIN | Meta analysisP |
||||||
|---|---|---|---|---|---|---|---|---|---|
| N, cases |
N, controls |
P | OR (95% CI)a | N, cases |
N, controls |
P | OR (95% CI)b | ||
| Heroin and other opioids |
1,294 | 1,725 | 1.05×10−5 | 0.70 (0.60–0.82) | 113 | 496 | 0.16 | 0.70 (0.43–1.16) | 4.48×10−6 |
| Cocaine | 870 | 1,725 | 1.50×10−4 | 0.71 (0.59–0.85) | 112 | 496 | 0.13 | 0.67 (0.40–1.12) | 4.58×10−5 |
| Marijuana | 35 | 1,725 | 0.78 | 0.91 (0.46–1.81) | 212 | 496 | 0.0010 | 0.47 (0.30–0.74) | 0.046 |
| Amphetamines and other stimulants |
113 | 1,725 | 0.12 | 0.71 (0.45–1.10) | 48 | 496 | 0.83 | 0.83 (0.43–1.63) | 1.16×10−5 |
CI, confidence interval; OR, odds ratio
a
Models were adjusted for sex and eigenvectors.
b
Models were adjusted for sex, eigenvectors, alcohol abuse and nicotine dependence.