Table 4.
Outcomes of treatment
| Hospital | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A | B | C | D | E | F | G | ||||||||
| Pre | Post | Pre | Post | Pre | Post | Pre | Post | Pre | Post | Pre | Post | Pre | Post | |
| Recurrences/primary episodes (%) | 7/66 (10.6%) | 1/32 (3.1%) | 16/98 (16.3%) | 2/64 (3.1%) | 19/246 (7.7%) | 22/265 (8.3%) | 15/71 (21.1%) | 7/56 (12.5%) | 15/116 (12.9%) | 11/93 (11.8%) | 15/89 (16.9%) | 8/89 (9.0%) | 6/112 (5.4%) | 4/69 (5.8%) |
| % Change in recurrence rate (pre to post) | −7.5% | −13.2% | +0.6% | −8.6% | −1.1% | −7.9% | +0.4% | |||||||
| Relative % change in recurrence rate | −70.1% | −81.0%, p=0.01 | +7.8% | −40.8% | −8.5% | −46.7% | +7.4% | |||||||
| Median time (days) to symptom resolution from diagnosis, primary episodes | 7.5 (n=46) | 13.0 (n=29), p<0.01 | 9.0 (n=92) | 9.0 (n=64) | 9.0 (n=45) | 10.0 (n=87), p=0.01 | 8.0 (n=62) | 7.0 (n=51) | 9.0 (n=93) | 10.0 (n=75) | 10.0 (n=80) | 10.0 (n=79) | 11.0 (n=74) | 11.0 (n=53) |
| Median LOSa (days) from diagnosis, primary episodes | 9.0 (n=54) | 19.0 (n=28), p=0.01 | 14.0 (n=90) | 19.0 (n=57) | 11.0 (n=57) | 9.5 (n=106) | 13.0 (n=51) | 15.0 (n=45) | 11.0 (n=77) | 12.0 (n=76) | 14.5 (n=76) | 16.0 (n=71) | 13.0 (n=77) | 15.0 (n=51) |
| ICU admission rate, following CDI diagnosis, primary episodes, n (%) | 7/66 (10.6%) | 2/32 (6.3%) | NKb | NKb | 1/79 (1.3%) | 2/140 (1.4%) | 1/70 (1.4%) | 1/56 (1.8%) | 2/116 (1.7%) | 3/93 (3.2%) | 1/89 (1.1%) | 0/89 (0.0%) | 1/112 (0.9%) | 0/69 (0.0%) |
| Readmission rate within 30 days of primary episode, n (%) | 16/54 (29.6%) | 2/27 (7.4%), p<0.05 | NKb | NKb | 10/58 (17.2%) | 32/109 (29.4%) | 10/51 (19.6%) | 7/46 (15.2%) | 9/83 (10.8%) | 9/78 (11.5%) | 16/76 (21.1%) | 18/70 (25.7%) | 19/78 (24.4%) | 9/53 (17.0%) |
| Median LOS (days) from diagnosis with recurrencec | 16.0 (n=5) | 5.5 (n=2) | 33.0 (n=14) | 40.0 (n=2) | 36.0 (n=5) | 11.0 (n=25) | 5.0 (n=3) | 0 (N/Ad) | 15.0 (n=15) | 8.0 (n=11) | 14.5 (n=12) | 23.0 (n=10) | 9.0 (n=5) | 27.0 (n=4) |
| Readmission rate within 30 days of recurrencec, n (%) | 2/5 (40.0%) | 0/2 (0.0%) | NKb | NKb | 3/5 (60.0%) | 11/25 (44.0%) | 1/3 (33.3%) | 0 (N/Ad) | 3/16 (18.8%) | 2/11 (18.2%) | 2/10 (20.0%) | 0/8 (0.0%) | 1/5 (20.0%) | 0/4 (0.0%) |
| 28-day all-cause mortality, primary episodes, n (%) | 12/66 (18.2%) | 1/32 (3.1%) p<0.05 | 17/98 (17.3%) | 4/64 (6.3%), p<0.05 | 16/77 (20.8%) | 23/138 (16.7%) | 20/70 (28.6%) | 5/55 (9.1%), p<0.05 | 25/109 (22.9%) | 18/90 (20.0%) | 13/89 (14.6%) | 20/89 (22.5%) | 34/112 (30.4%) | 13/69 (18.8%) |
aLength of stay
bNot known: data not provided
cLOS and 30-day readmission rate for recurrences are based on all recurrences, i.e. recurrences of primary CDI and further (second, third, fourth) recurrences
dNot applicable: n=0