. Author manuscript; available in PMC: 2016 Jan 24.

Published in final edited form as: JAMA Neurol. 2015 Sep;72(9):1021–1028. doi: 10.1001/jamaneurol.2015.1359

Table 2.

Cerebral Blood Flow and CMBs

	Any CMB(+) vs CMB(−)			Cortical CMB(+) vs Cortical CMB(−)
Region of Interest	% Change^a	Cohen d	P Value^b	% Change^a	Cohen d	P Value^b
Anterior cingulate	−11.9	0.62	.089	−21.6	1.19	.0014^c

Anterior ventral striatum	−9.6	0.43	.21	−14.9	0.68	.067
Cortex
Frontal	−16.1	0.78	.013	−26.1	1.31	.0004^c

Lateral temporal	−6.6	0.25	.53	−10.9	0.41	.34

Occipital	−12.6	0.54	.15	−16.6	0.70	.14

Parietal	−21.4	0.86	.015	−37.6	1.64	<.0001^c

Precuneus	−18.7	0.79	.027	−31.8	1.41	.0006^c

Global^d	−15.1	0.81	.022	−25.3	1.44	.0003^c

Abbreviations: CMB, cerebral microbleeds; CMB(+), with CMBs; CMB(−), without CMBs; PiB, Pittsburgh compound B; SUVR, standardized uptake value ratio.

Percent change = ([mean CBF in CMB(+) participants] − [mean CBF in CMB(−) participants]) / (mean CBF in CMB(−) participants).

P values calculated with an unpaired, 2-tailed t test.

P < .00625 (.05/8) was considered significant with Bonferroni correction for multiple comparisons.

Global values represent the mean of the anterior cingulate, anterior ventral striatum, frontal cortex, lateral temporal cortex, parietal cortex, and precuneus cortex ROIs. P values have been corrected for age, sex, and global PiB SUVR.