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Diagram depicting the formation of the Spätzle ligand in the ventral perivitelline space. VML-associated and free GD processes and activates Snake. Only GD that is associated with Pipe-sulfated VML promotes the interaction between activated Snake and the Easter zymogen, which leads to Easter cleavage and activation. Activated Easter then processes and converts Spätzle into the active Toll ligand. Active Easter is bound by and inactivated by Serpin 27A.
