Table 1. Tabulated Responses.

Compound	Relative response*	Potentiated response*
diEPP	0.002 ± 0.003	1.3 ± 0.3
1f, m-Chloro PEP	0.009 ± 0.008	0.1 ± 0.1
1n, p-CF3 PEP	0.000 ± 0.004	1.4 ± 0.7
1p, m-Bromo PEP	0.000 ± 0.003	6.9 ± 2.4
1r, p-fluoro PEP	0.000 ± 0.003	0.0 ± 0.0
2a, p-methyl	0.011 ± 0.003	3.6 ± 2.0
2b, p-cyano	0.234 ± 0.024	68.0 ± 25.4
2c, p-methoxy	0.063 ± 0.014	11.6 ± 0.3
2d, m-methyl	0.001 ± 0.000	0.2 ± 0.1
2e, p-chloro	0.234 ± 0.048	18.3 ± 6.2
2f, m-chloro	0.020 ± 0.003	4.2 ± 1.0
2g, m-methoxy	0.011 ± 0.011	0.6 ± 0.2
2h, o-methyl	0.319 ± 0.066	16.4 ± 2.4
2i, m-cyano	0.022 ± 0.024	1.5 ± 0.7
2j, o-chloro	0.367 ± 0.054	36.6 ± 6.1
2k, m-OH	0.283 ± 0.013	31.4 ± 5.1
2l, p,o-dimethoxy	0.014 ± 0.009	1.1 ± 0.1
2m, 2-naphthalene	0.143 ± 0.018	15.9 ± 2.3
2n, p-CF3	0.032 ± 0.003	61.8 ± 7.7
2o, m-CF3	0.000 ± 0.002	3.1 ± 2.1
2p, m-bromo	0.040 ± 0.006	10.0 ± 1.7
2q, p-bromo	0.270 ± 0.017	12.3 ± 3.5
2r, p-fluoro	0.010 ± 0.002	22.9 ± 5.8
2s, m-fluoro	0.061 ± 0.089	0.2 ± 0.1
2t, p-CONH2	0.065 ± 0.009	43.9 ± 8.5
2u, m-CONH2	0.056 ± 0.022	50.7 ± 8.5
6, diEPP analogue NH	0.002 ± 0.004	5.6 ± 2.1
8, diEPP analogue	0.071 ± 0.027	9.9 ± 3.1

^*Values are the mean ± SEM for N ≥ 4 experiments. All data are relative to the response of the receptor to 60 μM control applications of ACh. “Relative response” refers to receptor response to a 30 μM application of test compound. Potentiated response refers to receptor response with 30 μM test compound and 10 μM PNU-120596 co-application. Refer to experimental section for details.