Skip to main content
. Author manuscript; available in PMC: 2017 Jan 15.
Published in final edited form as: Bioorg Med Chem. 2015 Dec 9;24(2):286–293. doi: 10.1016/j.bmc.2015.12.017

Table 2. Partial agonist properties.

Estimated Rank
Compound Peak currenta Net Chargea Ratio potency efficacy PNU
responsea
o-chloro(2j) 0.23 ± 0.03 0.37 ± 0.05 0.63 4 2 37 ± 6
o-methyl(2h) 0.15 ± 0.02 0.32 ± 0.07 0.46 5 1 16 ± 2
m-hydroxy(2k) 0.19 ± 0.02 0.28 ± 0.02 0.67 3 4 31 ± 5
naphthalene(2m) 0.10 ± 0.02 0.14 ± 0.02 0.71 1 6 16 ± 2
p-chloro(2e) 0.17 ± 0.02 0.23 ± 0.05 0.71 1 5 18 ± 6
p-cyano(2b) 0.10 ± 0.01 0.23 ± 0.02 0.43 6 3 68 ± 25
a

Relative to 60 μM ACh controls (n ≥ 4)