Appendix Table 2.
Laboratory Results for Patient 2, the First Domestically Acquired Ebola Virus Disease Case in the United States, October 2014
| Variable | Illness Day (Date in 2014) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 (11 October) |
3 (12 October) |
4 (13 October) |
5 (14 October) |
6 (15 October) |
7 (16 October) (Transfer) |
8 (17 October) |
9 (18 October) |
10 (19 October) |
11 (20 October) |
12 (21 October) |
13 (22 October) |
14 (23 October) |
20 (29 October) |
27 (5 November) |
|
| Experimental therapy | - | BCV, CVP | CVP, TKM-Ebola | ZMapp, TKM-Ebola | BCV, TKM-Ebola | - | - | - | - | - | - | - | - | - | - |
| Hematology | |||||||||||||||
| Leukocyte count, × 109 cells/L | 4.10 (L) | 2.03 (L) | - | 3.52 (L) | 4.03 (L) | 3.39 (L) | 4.63 | 5.64 | 6.52 | 7.01 | 7.25 | 5.73 | 5.62 | 7.51 | 5.45 |
| Neutrophil count, × 109 cells/L | 3.01 | 1.64 (L) | - | 2.97 | 3.04 | 1.76 | 1.61 | 2.01 | 2.52 | 3.34 | 3.39 | 2.75 | 2.70 | 4.91 | 2.93 |
| Lymphocyte count, × 109 cells/L | 0.66 (L) | 0.23 (L) | - | 0.49 (L) | 0.74 (L) | 0.98 | 2.04 | 2.43 | 2.37 | 2.17 | 2.18 | 1.73 | 1.87 | 1.64 | 1.64 |
| Hemoglobin, g/dL | 13.9 | 12.6 | - | 10.5 (L) | 10.4 (L) | 11.8 | 12.0 | 10.9 (L) | 12.2 | 13.1 | 13.3 | 13.1 | 12.4 | 11.8 | 11.5 |
| Platelet count, × 109 cells/L | 343 | 193 | - | 67 (L) | 94 (L) | 108 (L) | 122 (L) | 166 | 214 | 290 | 340 | 375 | 417 | 601 | 457 |
| Serum levels | |||||||||||||||
| AST, U/L | 27 | 29 | 63 (H) | 140 (H) | 223 (H) | 224 (H) | 286 (H) | 337 (H) | 216 (H) | 152 (H) | 104 (H) | 83 (H) | 63 (H) | 26 | 27 |
| ALT, U/L | 26 | 28 | 53 (H) | 74 (H) | 191 (H) | 245 (H) | 311 (H) | 398 (H) | 376 (H) | 348 (H) | 300 (H) | 236 (H) | 188 (H) | 65 (H) | 38 |
| AP, U/L | 53 | 47 | 51 | 41 (L) | 48 | 64 | 79 | 107 | 123 | 138 | 146 | 133 | 116 | 109 (H) | 92 |
| Bilirubin, mg/dL | 0.1 | 0.1 | 0.2 | 0.2 | 0.3 | 0.4 | 0.8 | 0.8 | 0.9 | 0.9 | 0.9 | 0.8 | 0.8 | 0.5 | 0.3 |
| Albumin, g/dL | 3.8 | 3.4 | 3.4 | 3.9 | 3.8 | 4.1 | 4.3 | 4.1 | 4.3 | 4.2 | 4.5 | 4.4 | 4.4 | 4.1 | 3.5 |
| Creatinine, mg/dL | 0.76 | 0.62 | 0.65 | 0.58 | 0.59 | 0.62 | 0.3 | 0.5 | 0.4 | 0.6 | 0.5 | 0.6 | 0.5 | 0.6 | 0.6 |
| Sodium, mmol/L | 140 | 136 | 140 | 141 | 138 | 140 | 136 | 136 | 136 | 138 | 138 | 137 | 138 | 141 | 139 |
| Potassium, mmol/L | 3.7 | 3.5 | 3.9 | 3.9 | 3.7 | 6.4 | 3.7 | 3.7 | 3.9 | 4.3 | 4.0 | 4.2 | 3.9 | 3.8 | 3.7 |
| Chloride, mmol/L | 104 | 104 | 106 | 108 | 102 | 109 | 103 | 105 | 102 | 104 | 100 | 102 | 99 | 107 | 106 |
| CO2 content, mmol/L | 23 | 23 | 25 | 25 | 26 | 23 | 30 | 29 | 29 | 28 | 29 | 31 | 29 | 22 | 24 |
| Anion gap, mmol/L | 10 | 5 | 9 | 8 | 10 | 8 | 6.7 | 5.7 | 8.9 | 10.3 | 13 | 8.2 | 13.9 | 12 | 9 |
| LDH, U/L | - | - | - | 608 (H) | 318 (H) | - | - | - | - | - | - | - | - | - | - |
| CK, U/L | - | - | - | 154 | 161 | - | - | - | - | - | - | - | - | - | - |
| Maximum temperature, °C | 38.2 | 39.7 | 40.0 | 38.6 | 38.3 | AF | AF | AF | AF | AF | AF | AF | AF | AF | AF |
| Blood EBOV qRT-PCR result | Positive | Positive | Positive | u/d | Positive | u/d | u/d* | u/d* | - | u/d* | u/d*† | u/d* | u/d*‡ | - | - |
| Blood EBOV qRT-PCR Ct value | 32 | 30 | 36 | - | 38 | - | - | - | - | - | - | - | - | - | - |
| EBOV IgM antibody titer | u/d | u/d | u/d | u/d | ≥400 | ≥1600 | - | - | - | ≥6400 | - | - | - | - | - |
| EBOV IgG antibody titer | u/d | u/d | u/d | ≥400 | ≥6400 | ≥1600 | - | - | - | ≥1600 | - | - | - | - | - |
AF = afebrile; ALT = alanine aminotransferase; AP = alkaline phosphatase; AST = aspartate aminotransferase; BCV = brincidofovir; CK = creatine kinase; Ct = cycle threshold (lower values reflect higher viral loads); CVP = convalescent plasma; EBOV = Ebola virus; H = high (above reference range); L = low (below reference range); LDH = lactate dehydrogenase; qRT-PCR = quantitative reverse transcriptase polymerase chain reaction; u/d = undetectable level (negative result). Dashes indicate no results on these days.
RT-PCR performed at U.S. Army Medical Research Institute of Infectious Diseases, which measures nucleoprotein and glycoprotein. Initial qRT-PCR was performed at the Centers for Disease Control and Prevention, targeting the nucleoprotein gene.
Result was also negative from urine and throat, rectal, and vaginal swabs.
Result was also negative from axillary skin sweat.