Appendix Table 3.
Laboratory Results for Patient 3, the Second Domestically Acquired Ebola Virus Disease Case in the United States, October 2014
| Variable | Illness Day (Date in 2014) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 (14 October) |
6 (15 October) (Transfer) |
7 (16 October) |
8 (17 October) |
9 (18 October) |
10 (19 October) |
11 (20 October) |
12 (21 October) |
13 (22 October) |
14 (23 October) |
15 (24 October) |
16 (25 October) |
17 (26 October) |
18 (27 October) |
25 (3 November) |
32 (10 November) |
40 (18 November) |
|
| Experimental therapy | BCV | CVP | CVP | BCV | - | - | - | - | - | - | - | - | - | - | - | - | |
| Hematology | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| Leukocyte count, ×
109 cells/L |
2.67 (L) | 3.55 (L) | 6.2 | 4.8 | 6.3 | 6.3 | 5.6 | 6.6 | 6.0 | 6.1 | 5.4 (L) | 5.2 | 5.8 | 6.2 | 5.8 | 4.8 | 6.1 |
| Neutrophil count, ×
109 cells/L |
1.95 | 2.22 | - | - | - | - | - | - | - | - | - | - | - | - | 2.3 | 2.5 | 3.8 |
| Lymphocyte count, ×
109 cells/L |
0.62 (L) | 0.97 | 2.72 | 1.79 | 1088 | ||||||||||||
| Hemoglobin, g/dL | 15.8 | 14.5 | 12.2 | 12.2 | 12.2 | 12.2 | 13.5 | 13.9 | 12.2 | 12.6 | 11.2 (L) | 10.9 (L) | 11.1 (L) | 12.1 | 13.7 | 13.5 | 13.4 |
| Platelet count, × 109 cells/L | 120 (L) | 114 (L) | 197 | 116 | 140 (L) | 195 | 236 | 309 | 305 | 346 | 341 | 320 | 311 | 336 | 248 | 206 | 170 |
| Serum levels | |||||||||||||||||
| AST, U/L | 255 (H) | 306 (H) | 195 (H) | 154 (H) | 241 (H) | 491 (H) | 393 (H) | 379 (H) | 293 (H) | 361 (H) | 318 (H) | 251 (H) | 183 (H) | 178 (H) | 42 | 27 | 24 |
| ALT, U/L | 175 (H) | 259 (H) | 204 (H) | 188 (H) | 273 (H) | 512 (H) | 557 (H) | 654 (H) | 575 (H) | 719 (H) | 698 (H) | 635 (H) | 534 (H) | 533 (H) | 137 | 57 | 35 |
| AP, U/L | 70 | 58 | 53 | 62 | 60 | 71 | 80 | 80 | 69 | 82 | 64 | 58 | 58 | 62 | 76 | 72 | 65 |
| Bilirubin, mg/dL | 0.5 | 0.5 | 0.6 | 0.5 | 0.5 | 0.5 | 0.6 | 0.6 | 0.6 | 0.6 | 0.8 | 0.7 | 0.7 | 0.8 | 0.2 | 0.4 | 0.5 |
| Albumin, g/dL | 3.5 | 2.8 (L) | 3.0 (L) | 3.2 (L) | 3.3 (L) | 3.2 (L) | 3.5 | 3.7 | 3.5 | 3.7 | 3.3 (L) | 3.2 (L) | 3.2 (L) | 3.5 | 3.8 | 3.6 | 3.7 |
| Creatinine, mg/dL | 0.7 | 0.6 | 0.7 | 0.6 | 0.7 | 0.7 | 0.7 | 0.6 | 0.7 | 0.6 | 0.6 | 0.6 | 0.7 | 0.7 | 0.7 | 0.7 | 0.7 |
| Sodium, mmol/L | 136 | 136 | 136 | 141 | 149 | 143 | 141 | 142 | 138 | 140 | 139 | 138 | 137 | 138 | 137 | 139 | 137 |
| Potassium, mmol/L | 3.5 | 3.8 | 3.5 | 3.7 | 4.0 | 3.9 | 3.9 | 4.3 | 3.9 | 4.1 | 4.7 | 3.9 | 4.1 | 4.1 | 4.4 | 3.5 | 3.9 |
| Chloride, mmol/L | 102 | 108 | 106 | 109 | 111 | 107 | 107 | 105 | 105 | 107 | 107 | 108 | 108 | 107 | 105 | 109 | 108 |
| CO2 content, mmol/L | 21 | 19 | 26 | 27 | 28 | 28 | 27 | 28 | 26 | 25 | 26 | 27 | 26 | 28 | 21 | 21 | 19 |
| Anion gap, mmol/L | 13 | 9 | 4 | 5 | 10 | 8 | 7 | 9 | 7 | 8 | 6 | 11 | 3 | 3 | - | - | 10 |
| LDH, U/L | - | 751 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| CK, U/L | - | 238 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| Maximum temperature, °C | 38.9 | 38.9 | AF | AF | AF | AF | AF | AF | AF | AF | AF | AF | AF | AF | AF | AF | AF |
| Blood EBOV qRT-PCR result | Positive | Positive | Positive | Positive | - | u/d | u/d | u/d | u/d | u/d | u/d | - | - | - | - | - | |
| Blood EBOV qRT-PCR Ct value | 30 | 33 | 37 | 37 | - | - | - | - | - | - | - | - | - | - | - | - | |
| Urine EBOV qRT-PCR result | - | Positive | Positive | Positive | Positive | - | Positive | u/d | u/d | u/d* | u/d | - | * | - | - | - | |
| Urine EBOV qRT-PCR Ct value | - | 34 | 35 | 39 | 38 | - | 39.5 | - | - | - | - | - | - | - | - | - | |
| EBOV IgM antibody titer | u/d | u/d | ≥400 | ≥1600 | - | ≥6400 | ≥6400 | ≥6400 | ≥6400 | - | >1600 | - | - | - | - | - | |
| EBOV IgG antibody titer | u/d | u/d | ≥400 | ≥1600 | - | ≥1600 | ≥1600 | ≥6400 | ≥6400 | - | >1600 | - | - | - | - | - | |
AF = afebrile; ALT = alanine aminotransferase; AP = alkaline phosphatase; AST = aspartate aminotransferase; BCV = brincidofovir; CK = creatine kinase; Ct = cycle threshold (lower values reflect higher viral loads); CVP = convalescent plasma; EBOV = Ebola virus; H = high (above reference range); L = low (below reference range); LDH = lactate dehydrogenase; qRT-PCR = quantitative reverse transcriptase polymerase chain reaction; u/d = undetectable level (negative result). Dashes indicate no results on these days.
*
Result was also negative from skin and vaginal fluid.