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. Author manuscript; available in PMC: 2017 Feb 10.
Published in final edited form as: J Control Release. 2015 Dec 19;223:75–84. doi: 10.1016/j.jconrel.2015.12.028

Figure 4. In vivo therapeutic efficacy of the MPs under rotating magnetic field.

Figure 4

(A) The rotating MF setup for animal experiments. (B) In vivo design of animal studies. The U87 cells were pre-incubated with MPs for 24 hours and implanted in the mouse brain. At day 4 after tumor implantation, animals received 1 hour long daily exposures to the MF for 7 days starting. (C) In vivo bioluminescence images of the glioma bearing mice with MPs. MPs loaded U87 glioma cells were labeled with firefly luciferase. Bioluminescence images were taken at day 7, 14, 21 and 28 days post tumor implantation. (D) Quantification of the tumor bioluminescence signal over 4 weeks (n = 5 mice per group). Data are presented as Mean±SE. ** p<0.01, *** p<0.001 (Student’s t test). (E) Kaplan-Meier survival curve of the mice with and without MF treatment. * p<0.05 (Log rank test).