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. Author manuscript; available in PMC: 2017 Jan 15.
Published in final edited form as: Dev Biol. 2015 Nov 7;409(2):329–342. doi: 10.1016/j.ydbio.2015.09.024

Figure 4.

Figure 4

Evidence of dysphagia in LgDel neo-natal mice. A. Left: Growth curves for 22q11DS patients from birth through 3 years of age (a time when all 22q11DS patients have dysphagic syndromes) in females (pink) and males (blue). Female and male 22q11DS patients have equivalent slowing of weight gain. Right: Growth curves for LgDel female (pink) and male (blue) mice from birth through 30 days of age (identified individually and weighed daily) show similar diminished weight gain in the 22q11DS model mice. B. Aspiration infections in the nasopharynx of Postnatal day 7 (P7) LgDel mouse. Left: There are protein accumulations that are infiltrated with leukocytes (*asterisks). Right: These accumulations are composed primarily of murine milk protein (red inset), and are coincident with accumulations of neutrophils (blue inset). C. Acute aspiration of milk (labeled with fluorescent green microspheres) into the nasopharynx (NP) of LgDel (right) but not Wild Type (WT) P7 mouse pups. To = tongue. Figure adapted from (Karpinski et al., 2014, Meechan et al., 2015).