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. Author manuscript; available in PMC: 2017 Jan 15.
Published in final edited form as: Dev Biol. 2015 Nov 30;409(2):406–419. doi: 10.1016/j.ydbio.2015.11.022

Figure 2. Tuba1aND/ND brains have hallmarks of tubulinopathy.

Figure 2

(A,B) Hoechst staining of E18.5 Tuba1aND/+ and Tuba1aND/ND whole brains. (OLF, Olfactory bulb; CTX, Cortex; HB, Hindbrain). Scalebar = 1000μm. (C,D) Cross section of H&E stained E18.5 Tuba1aND/+ and Tuba1aND/ND brains. Scalebar = 1000μm. (E,F) Higher magnification of cortex from panel (C) and (D) to demonstrate cortical layering in Tuba1aND/+ and Tuba1aND/ND, respectively. Scalebar = 200μm. (G,H) H&E stained coronal plane from Tuba1aND/+ and Tuba1aND/ND embyros show hippocampus and midbrain impairment in Tuba1aND/ND. Scalebar = 200μm. (I,J) H&E stained cross sections of the hindbrain in Tuba1aND/+ and Tuba1aND/ND embryos. Scalebar = 500μm.