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. Author manuscript; available in PMC: 2017 Jan 15.
Published in final edited form as: Dev Biol. 2015 Dec 3;409(2):382–391. doi: 10.1016/j.ydbio.2015.11.024

Figure 6. Loss ofPRR in nephron progenitors results in small cystic kidneys.

Figure 6

(A–I) Hematoxylin and eosin-stained sections of P0 kidneys from control (A–C), heterozygous (D–F) and Six2PRR−/− (G–I) mice demonstrate reduced kidney size, lack of well-defined nephrogenic zone, thin cortex with apparent reduction in nephron number, presence of cysts (Cy) in the cortex and medulla in Six2PRR−/− mutants. (A,D,G) scale bar= 100 µm; numbers- kidney length. (J,K) Bar graphs demonstrate a decrease in total nephron number (J) and in number of all nephron generation stages (K) Six2PRR−/− mutants compared to controls.