Table 1.
Clinical and PET Measures for PD subjects
| Total group (n=133) |
H-Y≤2 (n=42) |
H-Y>2 (n=91) |
|
|---|---|---|---|
| Age (years) | 65.4 ± 7.5 | 62.6 ± 7.2 | 66.7 ± 7.3 |
| Gender | 96M/37F | 33M/9F | 63M/28F |
| Disease duration | 6.1 ± 4.3 | 4.5 ± 3.5 | 6.8 ± 4.4 |
| LED (mg) | 673.6 ± 508.3 | 593.2 ± 389.5 | 710.8 ± 552.6 |
| FSS | 3.2 ± 1.5 | 2.9 ± 1.6 | 3.3 ± 1.4 |
| MDS-UPDRS | |||
| nM-EDL | 6.5 ± 4.5 | 5.3 ± 4.1 | 7.0 ± 4.7 |
| M-EDL | 8.1 ± 5.8 | 4.9 ± 3.7 | 9.5 ± 6.0 |
| Motor | 31.8 ± 13.7 | 23.8 ± 10.1 | 35.4 ± 13.6 |
| ESS | 8.7 ± 4.5 | 7.2 ± 4.2 | 9.4 ± 4.5 |
| ISI | 7.2 ± 5.9 | 7.0 ± 5.4 | 7.4 ± 6.2 |
| BDI | |||
| Total score | 7.9 ± 6.1 | 7.7 ± 6.7 | 8.0 ± 5.8 |
| Affective subscale | 1.7 ± 2.4 | 1.8 ± 2.9 | 1.7 ± 2.1 |
| Somatic subscale | 6.2 ± 4.3 | 5.9 ± 4.4 | 6.4 ± 4.2 |
| Apathy Evaluation Scale | 24.4 ± 6.0 | 23.1 ± 5.8 | 25.0 ± 6.0 |
| STAI | 37.1 ± 6.4 | 37.0 ± 7.2 | 37.2 ± 6.0 |
| Global cognitive composite z-scorea | −0.36 ± 0.91 | −0.008 ± 0.72 | −0.53 ± 0.94 |
| PET measures | |||
| Striatal DTBZ | 1.92 ± 0.28 | 2.01 ± 0.27 | 1.88 ± 0.28 |
| Thalamus PMP | 0.054 ± 0.005 | 0.053 ± 0.005 | 0.055 ± 0.005 |
| Neocortex PMP | 0.024 ± 0.003 | 0.024 ± 0.002 | 0.023 ± 0.003 |
a
Using our neuropsychological test battery, composite z-scores were calculated for four cognitive domains (memory, executive, attention and visuospatial functions) based on normative data. The global cognitive composite z-score was calculated as the average of the four domain z-scores
H-Y = Modified Hoehn and Yahr
LED = Levodopa equivalent dose
FSS = Fatigue Severity Scale
MDS-UPDRS nM-EDL = Non-motor experiences of daily living
MDS-UPDRS M-EDL = Motor experiences of daily living
ESS = Epworth Sleepiness Scale
ISI = Insomnia Severity Index
BDI = Beck Depression Inventory
STAI = State-Trait Anxiety Inventory
DTBZ = [11C] dihydrotetrabenazine
PMP = [11C] methyl-4-piperidinyl propionate