Figure 5. Expression of Unc93b1 in hematopoietic cells is required for the development of Unc93b1-dependent clinical manifestations.
A) Clinical inflammation scores. B) Representative histologic images of inflammation in the ankle (upper panel) and midfoot (lower panel). Arrow designates synovium and arrowhead marks cellular infiltrate in the talus. Final magnification 4x. C) Quantitation of degree of bone marrow (BM) cellularity. D) Spleen weights. E) Representative ANA staining patterns of chimeric sera (original magnification x 200). All analyses performed on female chimeric mice. Data is representative of 2 individual experiments. Values are the mean ± SEM; *=p<0.05, ***=p<0.001 compared to DKO→Het.