Table 1.
Baseline Characteristics of 19,411 Participants Stratified by eGFR Category and Racial/Ethnic Group
| Characteristic | eGFR ≥105 (n = 2702 [13.9%]) |
eGFR 90 – <105 (n = 6529 [33.6%]) |
eGFR 75 – <90 (n = 5953 [30.7%]) |
eGFR 60 – <75 (n = 3127 [16.1%]) |
eGFR 45 – <60 (n = 904 [4.7%]) |
eGFR <45 (n = 196 [1.0%]) |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AA | H | W | AA | H | W | AA | H | W | AA | H | W | AA | H | W | AA | H | W | |
| No. of participants | 2241 | 313 | 148 | 1962 | 1569 | 2998 | 1800 | 687 | 3466 | 999 | 361 | 1767 | 335 | 106 | 463 | 99 | 18 | 79 |
| Age category | ||||||||||||||||||
| 50–59 y | 59.9 | 94.6 | 77.7 | 41.0 | 56.0 | 24.2 | 35.8 | 34.9 | 8.7 | 24.6 | 30.5 | 5.4 | 18.5 | 19.8 | 1.9 | 18 | 39 | 5 |
| 60–69 y | 37.8 | 5.4 | 20.9 | 44.3 | 40.0 | 60.5 | 46.3 | 47.3 | 43.3 | 47.8 | 47.4 | 41.9 | 45.7 | 51.9 | 34.1 | 35 | 33 | 30 |
| 70–79 y | 2.3 | 0.0 | 1.4 | 14.7 | 4.0 | 15.3 | 17.9 | 17.8 | 48.0 | 27.5 | 22.2 | 52.6 | 35.8 | 28.3 | 63.9 | 47 | 28 | 65 |
| Diabetes | 15.7 | 14.7 | 17.6 | 11.5 | 7.6 | 7.3 | 10.3 | 5.7 | 5.9 | 13.0 | 5.5 | 5.6 | 20.3 | 15.1 | 6.7 | 42 | 11 | 18 |
| History of MI | 2.2 | 0.6 | 2.7 | 2.4 | 1.1 | 2.5 | 3.6 | 1.9 | 2.9 | 4.8 | 2.5 | 3.8 | 8.4 | 3.8 | 4.8 | 11 | 6 | 10 |
| History of stroke | 1.6 | 0.6 | 0.0 | 1.9 | 1.2 | 0.8 | 2.2 | 1.5 | 1.3 | 3.0 | 2.5 | 1.7 | 3.9 | 4.7 | 1.3 | 17 | 6 | 10 |
| BMI | ||||||||||||||||||
| Underweight | 0.6 | 0.3 | 0.0 | 0.3 | 0.6 | 0.8 | 0.4 | 0.3 | 0.6 | 0.8 | 0.8 | 0.5 | 0.6 | 0.0 | 0.4 | 1 | 0 | 0 |
| Normal | 16.7 | 22.4 | 19.6 | 16.1 | 25.3 | 27.1 | 15.6 | 26.1 | 29.4 | 16.2 | 24.9 | 28.1 | 14.0 | 22.6 | 23.3 | 10 | 6 | 17 |
| Overweight | 32.3 | 33.5 | 25.0 | 33.5 | 38.8 | 32.9 | 34.4 | 41.6 | 35.8 | 33.6 | 41.0 | 36.7 | 34.6 | 29.2 | 39.1 | 36 | 44 | 29 |
| Obese | 50.4 | 43.8 | 55.4 | 50.2 | 35.3 | 39.3 | 49.6 | 32.0 | 34.5 | 49.3 | 33.2 | 34.6 | 50.7 | 48.1 | 37.1 | 53 | 50 | 54 |
| Alcohol use | ||||||||||||||||||
| Non drinker | 15.3 | 19.5 | 8.8 | 14.6 | 16.3 | 10.3 | 15.4 | 16.3 | 11.5 | 18.4 | 18.3 | 10.1 | 21.8 | 20.8 | 13.0 | 23 | 33 | 15 |
| Past drinker | 31.5 | 20.4 | 21.6 | 33.5 | 20.7 | 18.88 | 31.3 | 21.8 | 16.6 | 33.1 | 21.1 | 17.8 | 39.4 | 26.4 | 20.5 | 47 | 22 | 30 |
| Current drinker | 53.2 | 60.1 | 69.6 | 51.9 | 63.0 | 70.9 | 53.3 | 61.9 | 71.9 | 48.4 | 60.7 | 72.1 | 38.8 | 52.8 | 66.5 | 30 | 44 | 54 |
| Smoking status | ||||||||||||||||||
| Never Smoked | 44.8 | 60.4 | 39.9 | 48.4 | 62.7 | 46.2 | 49.5 | 61.1 | 52.5 | 51.2 | 68.4 | 56.1 | 55.2 | 63.2 | 55.1 | 48 | 56 | 46 |
| Past Smoker | 40.8 | 30.0 | 46.6 | 40.8 | 30.0 | 41.1 | 39.5 | 33.2 | 40.5 | 40.1 | 28.0 | 38.0 | 64.9 | 32.1 | 37.8 | 39 | 33 | 43 |
| Current Smoker | 14.3 | 9.6 | 13.5 | 10.8 | 7.4 | 12.8 | 11.0 | 5.7 | 7.0 | 8.7 | 3.6 | 5.9 | 9.9 | 4.7 | 7.1 | 13 | 11 | 11 |
| Physical activity | ||||||||||||||||||
| Sedentary: 0 MET-h/wk | 25.4 | 25.9 | 28.4 | 21.6 | 19.4 | 18.5 | 21.2 | 19.5 | 17.5 | 22.9 | 22.7 | 16.0 | 23.3 | 20.8 | 27.0 | 29 | 33 | 27 |
| Low: 0.1–<5 MET-h/wk | 24.9 | 26.2 | 28.4 | 24.3 | 24.7 | 23.7 | 25.8 | 22.9 | 22.6 | 24.0 | 21.9 | 23.1 | 29.6 | 24.5 | 22.9 | 25 | 33 | 30 |
| Moderate: 5–11.9 MET-h/wk | 22.8 | 24.6 | 27.7 | 23.2 | 24.0 | 23.8 | 23.3 | 22.6 | 24.2 | 24.4 | 22.4 | 25.0 | 20.3 | 17.9 | 18.8 | 22 | 11 | 20 |
| High: ≥12 MET-h/wk | 26.9 | 23.3 | 15.5 | 30.9 | 32.0 | 34.0 | 29.7 | 35.1 | 35.7 | 28.6 | 33.0 | 35.9 | 26.9 | 36.8 | 31.3 | 23 | 22 | 23 |
| SBP (mm Hg) | 130 (21) | 122 (24) | 126 (20) | 130 (21) | 122 (23) | 128 (23) | 130 (22) | 124 (25) | 130 (22) | 131 (25) | 124 (23) | 129 (22) | 135 (29) | 131 (24) | 133 (23) | 142 (30) | 132 (22) | 134 (24) |
| Cholesterol | ||||||||||||||||||
| Total (mg/dL) | 218 (53) | 218 (53) | 234 (56) | 220 (49) | 222 (51) | 230 (51) | 222 (52) | 222 (52) | 233 (51) | 230 (57) | 226 (59) | 234 (50) | 237 (63) | 237 (69) | 236 (54) | 254 (69) | 230 (122) | 243 (63) |
| HDL (mg/dL) | 55 (19) | 49 (16) | 47 (17) | 56 (18) | 51 (17) | 51 (15) | 54 (19) | 52 (16) | 51 (16) | 54 (19) | 51 (17) | 51 (15) | 57 (24) | 51 (17) | 50 (16) | 56 (20) | 47 (18) | 48 (15) |
| LDL (mg/dL) | 139 (51) | 137 (46) | 150 (49) | 143 (49) | 139 (46) | 148 (47) | 145 (50) | 140 (49) | 152 (46) | 152 (53) | 144 (50) | 152 (46) | 154 (61) | 159 (57) | 153 (51) | 165 (53) | 140 (90) | 157 (59) |
| TG (mg/dL) | 94 (60) | 133 (83) | 130 (105) | 95 (61) | 135 (89) | 126 (91) | 96 (59) | 129 (88) | 127 (84) | 102 (59) | 135 (70) | 130 (79) | 109 (78) | 140 (91) | 141 (96) | 130 (77) | 199 (108) | 155 (121) |
| CRP (mg/L) | 3.8 (6.6) | 4.0 (5.4) | 4.1 (7.4) | 3.5 (6.0) | 3.1 (4.7) | 2.4 (3.9) | 3.5 (6.0) | 2.7 (4.4) | 2.1 (3.3) | 3.6 (6.0) | 2.8 (4.0) | 2.2 (3.1) | 4.0 (7.1) | 3.9 (4.6) | 2.6 (3.9) | 6.3 (7.7) | 4.5 (10.7) | 4.3 (6.4) |
| Physical function | 85 (30) | 90 (20) | 80 (35) | 85 (34) | 90 (20) | 85 (20) | 85 (35) | 85 (25) | 85 (25) | 80 (40) | 85 (30) | 85 (25) | 70 (40) | 75 (40) | 80 (30) | 60 (35) | 78 (43) | 70 (50) |
Note: eGFR categories expressed in mL/min/1.73 m2. Values for categorical variables are given as number (percentage); for continuous variables, as median [interquartile range]. Conversion factor for cholesterol in mg/dL to mmol/L, ×0.02586.
Abbreviations: AA, African American; BMI, body mass index; eGFR, estimated glomerular filtration rate; H, Hispanic; HDL, high-density lipoprotein; LDL, low-density lipoprotein; MET, metabolic equivalent task; MI, myocardial infarction; SBP, systolic blood pressure; W, non-Hispanic white; TG, triglycerides; CRP, C-reactive protein