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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: J Immunol. 2016 Jan 6;196(3):1044–1059. doi: 10.4049/jimmunol.1501962

Figure 8. Spontaneous preterm labor/birth is associated with an increased proportion of activated iNKT-like cells in decidual tissues.

Figure 8

(A) Schematic representation to localize the decidua basalis and decidua parietalis. (B) Gating strategy used to identify activated iNKT-like cells (CD69+CD56+CD3+CD19-CD14-CD15- cells) in human decidual tissue. (C) Activated i-iNKT-like cells in the decidual basalis or decidual parietalis from women who underwent spontaneous term labor (TIL) or spontaneous preterm labor (PTL). Controls included samples from women who delivered at term (TNL) or preterm (PTNL) without labor. Data are from individual women: n=7 for TNL, n=27 for TIL, n=13 for PTNL, and n=14 for PTL. (D) Identification of CD3+Vα24Jα18TCR+CD69+ cells in PTL decidual tissues. (E) Identification of activated iNKT-like cells in the decidua parietalis by confocal microscopy. Nuclei are blue (DAPI), CD3+ cells are red (Alexa Fluor 594), CD56+ cells are magenta (APC), and CD69+ cells are green (FITC). White arrows represent activated NKT cells. Scale bars: 20 μm.