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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: J Immunol. 2016 Jan 4;196(3):1355–1365. doi: 10.4049/jimmunol.1500793

Figure 10. Injection of mice with annexin A2 causes glomerular complement activation.

Figure 10

Unmanipulated mice and mice subjected to renal ischemia/reperfusion were injected with 75 μg of recombinant annexin A2 and sacrificed after 24 hours. A) Immunofluorescence microscopy demonstrated glomerular C3b deposition. Original magnification 400X. B) Glomerular C3b deposits were significantly greater in mice injected with recombinant annexin A2 after renal ischemia/reperfusion than in those injected with a vehicle control. The C) serum urea nitrogen and D) serum creatinine levels were not significantly different in mice injected with recombinant annexin A2 compared with vehicle controls.