Table 1. Baseline demographic and clinical characteristics.

	AON cohort	MS Control Cohort*	P-value
Patients (eyes)	33 (65)	33 (66)	-
Age, y, mean (SD)	36.3 (9.5)	35.9 (9.1)	0.85a
Female, n (%)	29 (88)	29 (88)	1.00b
Race, n (%) ‡			0.31b
White	22 (67)	28 (85)
Black	7 (21)	4 (12)
Hispanic	2 (6)	0 (0)
Other	2 (6)	1 (3)
Disease duration, years, median (IQR)	1.25 (0.5-8)	7 (3-11)	0.009c
Eyes with a previous history of AON, n (%)	12 (18.2)	19 (28.8)	0.15d
Follow-up duration, months, median (IQR)	22.8 (12.6-34.2)	23.6 (14.2-36.1)	0.68c

Abbreviations: AON = Acute optic neuritis; MS = multiple sclerosis; SD = standard deviation; CIS = clinically isolated syndrome; RRMS = relapsing-remitting multiple sclerosis; IQR = interquartile range.

^*No patients in this cohort had AON at study entry or developed AON during follow-up.

^‡Race was self-reported.

^aTwo-sample Student's t-test.

^bFisher's exact test.

^cMann–Whitney U test.

^dChi-squared test.