Table 1.
MicroRNA de-regulation in gallbladder cancer
| Ref. | Source | miRNA | Level | Target gene | Functional characterization | Clinical association with | Function |
| Kitamura et al[121], 2012 | GBCs from BK5.erbb2 mice vs GBC from wild-type mice | mir-106a, mir-96 mir-223 mir-27a mir-17 mir-15b mir-142-5p mir-142-3p mir-21 | ↑ | - | - | - | - |
| mir-665 mir-714 mir-763 mir-466f-3p mir-145 mir-193 mir-467e mir-143 mir-881 mir-720 mir-706 -mir-122 mir-378 | ↓ | - | - | - | - | ||
| Li et al[133], 2015 | Paired GBC, normal tissue and blood samples | mir-21, mir-370, mir-187, mir-122, mir-202 | ↑ | - | - | mir-187, mir-143, mir-202 were associated with metastasis, TNM | - |
| let-7a, mir-200b, mir-143, mir-31, mir-335, mir-551 | ↓ | ||||||
| Peng et al[125], 2013 | Paired GBC, normal tissue | mir-335 | ↓ | - | - | Histologic grade, stage, metastasis, poor survival | - |
| Zhou et al[127], 2014 | Paired GBC, paracancerous tissue | mir-106a, mir-96 mir-223 mir-27a mir-17 mir-15b mir-142-5p mir-142-3p mir-21 | ↑ | - | - | - | - |
| mir-665 mir-714 mir-763 mir-466f-3p mir-145 mir-193 mir-467e mir-143 mir-881 mir-720 mir-706 -mir-122 mir-378 | ↓ | - | - | - | - | ||
| hsa-mir-135a-5p | ↓ | VLDLR | Cell proliferation, cell cycle distribution | Histologic grade | TSG | ||
| Jin et al[126], 2014 | Paired GBC tissue, tissue | mir-34a | ↓ | PNUTS | Cell proliferation | Poor prognosis | TSG |
| Zhou et al[128], 2014 | Paired GBC, paracancerous tissue | mir-26a | ↓ | HMGA2 | Cell proliferation | Histological grade | TSG |
| Letelier et al[129], 2014 | Normal GB, GBC tissue | mir-133a/b, mir-143-3p/5p, mir-991-5p, mir-125b-5p, mir-29c-3p, mir-195-5p, mir-139-5p, mir-29c-5p, mir-100-5p, mir-148a-3p, mir-376c, mir-187-3p, mir-365a-3p, mir-29b-3p, mir-497-5p, mir-654-3p, mir-411-5p, mir-125a-5p, mir-26a-5p, mir-101-3p, mir-495, mir-381-3p, mir-154-5p, mir-99a-3p, mir-328, mir-299-5p, mir-30e-3p, mir-29b-2-5p, mir-379-5p, mir-140-5p, mir-24-1-5p, mir-101-5p | ↓ | Distinguish GBC from normal samples | - | - | |
| - | TSG | ||||||
| mir-145-3p/5p | ↓ | - | Cell growth, cell viability, apoptosis | - | TSG | ||
| mir-1 | ↓ | VEGF-A , AXL | Cell growth, cell viability, apoptosis | - | TSG | ||
| Ma et al[131], 2014 | Paired GBC, normal tissue | mir-130a | ↓ | - | Cell proliferation, invasion | - | TSG |
| Cai et al[130], 2015 | Paired GBC, normal tissue | mir-146b-5p | ↓ | EGFR | Apoptosis, G1 phase arrest | Carcinoma size, progression | TSG |
| Ma et al[132], 2015 | Paired GBC, normal tissue | mir-218-5p | ↓ | BMI-1 | Cell proliferation, invasion | - | TSG |
| Chang et al[123], 2013 | Paired GBC, normal GB tissue | mir-20a | ↑ | SMAD-7 | EMT, metastasis | Worse overall survival | OG |
| Kono et al[122], 2014 | Paired GBC, normal GB tissue | mir-155 | ↑ | - | Cell proliferation, invasion | Lymph node metastasis, invasion, poor prognosis | OG |
| Qiu et al[124], 2014 | GBC, normal tissue | mir-182 | ↑ | CADM1 | Cell migration, invasion | Metastasis | OG |
GBC: Gallbladder cancer; VLDR: Very-low-density-lipoprotein receptor; PNUTS: Phosphatase 1 nuclear targeting subunit; HMGA2: High-mobility group AT-hook 2; VEGF-A: Vascular endothelial growth factor A; AXL: AXL receptor tyrosine kinase; EGFR: Epidermal growth factor receptor; BMI-1: Polycomb ring finger; SMAD-7: Mothers against DPP homolog 7; CADM1: Cell adhesion molecule 1.