Figure 1.

(Left) The nucleosome core particle: H3 (blue), H4 (green), H2A (yellow), H2B (red), and DNA (gray). (Right) The structures of the three L1 loop sequences considered in this study: canonical (top), macroH2A (middle), and H2A.Z (bottom). The canonical loops possess a net negative charge resulting from Glu⁴¹, whereas the macroH2A loops possess a net positive charge from Lys⁴⁰. The L1 loops of H2A.Z are uncharged, but both macroH2A and H2A.Z loops introduce a larger hydrophobic volume than the canonical. To see this figure in color, go online.