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. 2016 Jan 7;6(1):32–45. doi: 10.1016/j.apsb.2015.11.004

Table 1.

Structures and inhibitory activity against 5-LOX in rat peritoneal polymorphonuclear leukocytes (PMNLs). Inline graphic

Compd. R1 R2 Inhibition at 5 μmol/L (%)a
4a SO2NH2 graphic file with name fx3.gif 55.7
4b SO2NH2 graphic file with name fx4.gif 65.7
4c SO2NH2 graphic file with name fx5.gif 74.9
4d SO2NH2 graphic file with name fx6.gif 59.0
4e SO2NH2 graphic file with name fx7.gif 90.1
4f SO2NH2 graphic file with name fx8.gif 50.7
4g SO2NH2 graphic file with name fx9.gif 66.1
4h SO2NH2 graphic file with name fx10.gif 39.3
4i SO2NH2 graphic file with name fx11.gif 61.9
4j SO2NH2 graphic file with name fx12.gif 69.2
4k SO2NH2 graphic file with name fx13.gif 74.5
5a SO2CH3 graphic file with name fx14.gif 41.9
5b SO2CH3 graphic file with name fx15.gif 62.8
5c SO2CH3 graphic file with name fx16.gif 35.6
5d SO2CH3 graphic file with name fx17.gif 60.2
5e SO2CH3 graphic file with name fx18.gif 79.3
5f SO2CH3 graphic file with name fx19.gif 70.3
5g SO2CH3 graphic file with name fx20.gif 51.7
5i SO2CH3 graphic file with name fx21.gif 69.6
5j SO2CH3 graphic file with name fx22.gif 57.3
6a F graphic file with name fx23.gif 56.8
6b F graphic file with name fx24.gif 83.7
a

Values are means of three determinations and deviation from the mean is <10% of the mean value (Catalog No. 520111, Cayman Chemicals Inc.).