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Function of CD44 variant isoform (CD44v) in promoting resistance to oxidative stress. Alternative splicing of the CD44 gene results in the generation of multiple protein isoforms. CD44v8–10 is overexpressed in epithelial cancer stem cells, and their colocalization with the xCT subunit of system Xc(−), a glutamate/cystine antiporter, promotes the uptake of cystine and the consequent synthesis of the antioxidant glutathione, which reduces reactive oxygen species (ROS).
